TY - JOUR
T1 - Fas has a crucial role in the progression of experimental autoimmune encephalomyelitis
AU - Okuda, Yoshinobu
AU - Bernard, Claude C A
AU - Fujimura, Harutoshi
AU - Yanagihara, Takehiko
AU - Sakoda, Saburo
PY - 1998/4/1
Y1 - 1998/4/1
N2 - To investigate the role of Fas in experimental autoimmune encephalomyelitis (EAE) in mice, we examined the susceptibility of EAE in C57BL/6 (B6).lpr mice lacking Fas. The frequency of myelin oligodendrocyte glycoprotein (MOG)-induced EAE in B6.lpr mice was significantly lower than that in B6 mice (19% vs 94%). However, no significant difference was observed between them in either the lymphocyte proliferation response or antibody reactivity to MOG. In addition, the histological examination and semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that the infiltration of inflammatory cells and the up-regulation of gene expression for inflammatory cytokines occurred in the central nervous system (CNS) of B6.lpr mice immunized with MOG, even if they showed no clinical sign. These results indicate that Fas may contribute to the pathogenesis of EAE and may play a crucial role in the expansion of inflammation and/or myelin destruction in the CNS rather than in the activation of encephalitogenic T cells in the periphery and/or the breakdown of blood brain barrier.
AB - To investigate the role of Fas in experimental autoimmune encephalomyelitis (EAE) in mice, we examined the susceptibility of EAE in C57BL/6 (B6).lpr mice lacking Fas. The frequency of myelin oligodendrocyte glycoprotein (MOG)-induced EAE in B6.lpr mice was significantly lower than that in B6 mice (19% vs 94%). However, no significant difference was observed between them in either the lymphocyte proliferation response or antibody reactivity to MOG. In addition, the histological examination and semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that the infiltration of inflammatory cells and the up-regulation of gene expression for inflammatory cytokines occurred in the central nervous system (CNS) of B6.lpr mice immunized with MOG, even if they showed no clinical sign. These results indicate that Fas may contribute to the pathogenesis of EAE and may play a crucial role in the expansion of inflammation and/or myelin destruction in the CNS rather than in the activation of encephalitogenic T cells in the periphery and/or the breakdown of blood brain barrier.
KW - Cytokine
KW - Experimental autoimmune encephalomyelitis
KW - Fas
KW - Multiple sclerosis
KW - Myelin oligodendrocyte glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=0031868315&partnerID=8YFLogxK
U2 - 10.1016/S0161-5890(98)00049-2
DO - 10.1016/S0161-5890(98)00049-2
M3 - Article
C2 - 9747891
AN - SCOPUS:0031868315
SN - 0161-5890
VL - 35
SP - 317
EP - 326
JO - Molecular Immunology
JF - Molecular Immunology
IS - 5
ER -