FALL IN PLASMA-TESTOSTERONE LEVELS IN NORMAL MALE SUBJECTS IN RESPONSE TO AN ORAL GLUCOSE LOAD

J. R. Wall, R. J. Jarrett, P. Z. Zimmet, Marilyn Bailes, Christine M. Ramage

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16 Citations (Scopus)

Abstract

The response of plasma-testosterone to an oral glucose load was investigated in eight normal male subjects tested on two occasions, one week apart, at 9 A.M. and 2 P.M. Testosterone levels fell in fifteen out of sixteen tests, with a mean maximum fall of 34·3% (±S.E.M. 3·4%), and returned towards fasting levels by 150 minutes after the glucose load had been administered. By analogy with the effect of glucose on growth-hormone release, the suppression of luteinising hormone is a possible explanation of the fall in testosterone, although a direct effect of glucose on testosterone secretion, synthesis, or clearance is possible.

Original languageEnglish
Pages (from-to)967-968
Number of pages2
JournalThe Lancet
Volume301
Issue number7810
DOIs
Publication statusPublished - 5 May 1973
Externally publishedYes

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