FALL IN PLASMA-TESTOSTERONE LEVELS IN NORMAL MALE SUBJECTS IN RESPONSE TO AN ORAL GLUCOSE LOAD

J. R. Wall; R. J. Jarrett; P. Z. Zimmet; Marilyn Bailes; Christine M. Ramage

doi:10.1016/S0140-6736(73)91601-2

FALL IN PLASMA-TESTOSTERONE LEVELS IN NORMAL MALE SUBJECTS IN RESPONSE TO AN ORAL GLUCOSE LOAD

J. R. Wall, R. J. Jarrett, P. Z. Zimmet, Marilyn Bailes, Christine M. Ramage

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Abstract

The response of plasma-testosterone to an oral glucose load was investigated in eight normal male subjects tested on two occasions, one week apart, at 9 A.M. and 2 P.M. Testosterone levels fell in fifteen out of sixteen tests, with a mean maximum fall of 34·3% (±S.E.M. 3·4%), and returned towards fasting levels by 150 minutes after the glucose load had been administered. By analogy with the effect of glucose on growth-hormone release, the suppression of luteinising hormone is a possible explanation of the fall in testosterone, although a direct effect of glucose on testosterone secretion, synthesis, or clearance is possible.

Original language	English
Pages (from-to)	967-968
Number of pages	2
Journal	The Lancet
Volume	301
Issue number	7810
DOIs	https://doi.org/10.1016/S0140-6736(73)91601-2
Publication status	Published - 5 May 1973
Externally published	Yes

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10.1016/S0140-6736(73)91601-2

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Cite this

@article{e10026e0053c4f2bab024313fd54f41c,

title = "FALL IN PLASMA-TESTOSTERONE LEVELS IN NORMAL MALE SUBJECTS IN RESPONSE TO AN ORAL GLUCOSE LOAD",

abstract = "The response of plasma-testosterone to an oral glucose load was investigated in eight normal male subjects tested on two occasions, one week apart, at 9 A.M. and 2 P.M. Testosterone levels fell in fifteen out of sixteen tests, with a mean maximum fall of 34·3% (±S.E.M. 3·4%), and returned towards fasting levels by 150 minutes after the glucose load had been administered. By analogy with the effect of glucose on growth-hormone release, the suppression of luteinising hormone is a possible explanation of the fall in testosterone, although a direct effect of glucose on testosterone secretion, synthesis, or clearance is possible.",

author = "Wall, {J. R.} and Jarrett, {R. J.} and Zimmet, {P. Z.} and Marilyn Bailes and Ramage, {Christine M.}",

year = "1973",

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T1 - FALL IN PLASMA-TESTOSTERONE LEVELS IN NORMAL MALE SUBJECTS IN RESPONSE TO AN ORAL GLUCOSE LOAD

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AU - Jarrett, R. J.

AU - Zimmet, P. Z.

AU - Bailes, Marilyn

AU - Ramage, Christine M.

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