Fake Inhibitors: AMPK Activation Trumps Inhibition

Christopher G. Langendorf, John W. Scott, Bruce E. Kemp

Research output: Contribution to journalEditorialOtherpeer-review

3 Citations (Scopus)


Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal a novel off-target mechanism where the Src kinase inhibitor SU6656 paradoxically primes AMPK for phosphorylation and activation by the upstream kinase LKB1.

Original languageEnglish
Pages (from-to)775-777
Number of pages3
JournalCell Chemical Biology
Issue number7
Publication statusPublished - 20 Jul 2017
Externally publishedYes

Cite this