Failure of collateral blood flow is associated with infarct growth in ischemic stroke

Bruce CV Campbell; Soren Christensen; Brian M Tress; Leonid Churilov; Patricia M Desmond; Mark W Parsons; Peter Alan Barber; Christopher R Levi; Christopher Bladin; Geoffrey Donnan; Stephen M Davis

doi:10.1038/jcbfm.2013.77

Failure of collateral blood flow is associated with infarct growth in ischemic stroke

Bruce CV Campbell, Soren Christensen, Brian M Tress, Leonid Churilov, Patricia M Desmond, Mark W Parsons, Peter Alan Barber, Christopher R Levi, Christopher Bladin, Geoffrey Donnan, Stephen M Davis

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

252 Citations (Scopus)

Abstract

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated in humans. We correlated leptomeningeal collateral flow, assessed using novel perfusion magnetic resonance imaging (MRI) processing at baseline and 3 to 5 days, with simultaneous assessment of perfusion parameters. Perfusion raw data were averaged across three consecutive slices to increase leptomeningeal collateral vessel continuity after subtraction of baseline signal analogous to digital subtraction angiography. Changes in collateral quality, Tmax hypoperfusion severity, and infarct growth were assessed between baseline and days 3 to 5 perfusion-diffusion MRI. Acute MRI was analysed for 88 patients imaged 3 to 6 hours after ischemic stroke onset. Better collateral flow at baseline was associated with larger perfusion-diffusion mismatch (Spearman s Rho 0.51, P

Original language	English
Pages (from-to)	1168 - 1172
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	33
Issue number	8
DOIs	https://doi.org/10.1038/jcbfm.2013.77
Publication status	Published - 2013

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title = "Failure of collateral blood flow is associated with infarct growth in ischemic stroke",

abstract = "Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated in humans. We correlated leptomeningeal collateral flow, assessed using novel perfusion magnetic resonance imaging (MRI) processing at baseline and 3 to 5 days, with simultaneous assessment of perfusion parameters. Perfusion raw data were averaged across three consecutive slices to increase leptomeningeal collateral vessel continuity after subtraction of baseline signal analogous to digital subtraction angiography. Changes in collateral quality, Tmax hypoperfusion severity, and infarct growth were assessed between baseline and days 3 to 5 perfusion-diffusion MRI. Acute MRI was analysed for 88 patients imaged 3 to 6 hours after ischemic stroke onset. Better collateral flow at baseline was associated with larger perfusion-diffusion mismatch (Spearman s Rho 0.51, P",

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AU - Campbell, Bruce CV

AU - Christensen, Soren

AU - Tress, Brian M

AU - Churilov, Leonid

AU - Desmond, Patricia M

AU - Parsons, Mark W

AU - Barber, Peter Alan

AU - Levi, Christopher R

AU - Bladin, Christopher

AU - Donnan, Geoffrey

AU - Davis, Stephen M

PY - 2013

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Failure of collateral blood flow is associated with infarct growth in ischemic stroke

Abstract

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