Failure of collateral blood flow is associated with infarct growth in ischemic stroke

Bruce CV Campbell, Soren Christensen, Brian M Tress, Leonid Churilov, Patricia M Desmond, Mark W Parsons, Peter Alan Barber, Christopher R Levi, Christopher Bladin, Geoffrey Donnan, Stephen M Davis

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Abstract

Changes in collateral blood flow, which sustains brain viability distal to arterial occlusion, may impact infarct evolution but have not previously been demonstrated in humans. We correlated leptomeningeal collateral flow, assessed using novel perfusion magnetic resonance imaging (MRI) processing at baseline and 3 to 5 days, with simultaneous assessment of perfusion parameters. Perfusion raw data were averaged across three consecutive slices to increase leptomeningeal collateral vessel continuity after subtraction of baseline signal analogous to digital subtraction angiography. Changes in collateral quality, Tmax hypoperfusion severity, and infarct growth were assessed between baseline and days 3 to 5 perfusion-diffusion MRI. Acute MRI was analysed for 88 patients imaged 3 to 6 hours after ischemic stroke onset. Better collateral flow at baseline was associated with larger perfusion-diffusion mismatch (Spearman s Rho 0.51, P
Original languageEnglish
Pages (from-to)1168 - 1172
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number8
DOIs
Publication statusPublished - 2013

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