Failure of a daily haemofiltration programme using a highly permeable membrane to return β 2 -microglobulin concentrations to normal in haemodialysis patients

B. Canaud, A. Assounga, P. Kerr, R. Aznar, C. Mionc

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Abstract

In an attempt to return to normal serum β 2 -microglobulin levels in a group of seven ESRD patients, a programme of daily HF with highly permeable AN69 membranes was undertaken. Pre-HF β 2 -M serum levels stabilized after 4 days at 20 mg/1, only 40% lower than the initial concentration. A total of 985 ±20 mg β 2 -M was removed over the week. The β 2 -M release rate averaged 97 μg/min with a broad range of values (63-128 μg/min). β 2 -M release peaked at 602 μg/min 1 h after the end of the HF session before returning to baseline by 12 h post-HF. We conclude that a return to normal blood β 2 -M concentrations in ESRD patients seems quite unrealistic despite a highly intensive extracorporeal therapy. Therefore other therapeutic alternatives have to be designed to prevent or cure β 2 -M amyloidosis.

Original languageEnglish
Pages (from-to)924-930
Number of pages7
JournalNephrology Dialysis Transplantation
Volume7
Issue number9
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • End-stage renal disease
  • Haemofiltration
  • Highly permeable membranes
  • P< -M kinetic modelling
  • β -M
  • β -M amyloidosis

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