@article{45c73982f2f34c6f905a18e7a767db40,
title = "Factory and construction work is associated with an increased risk of severe lumbar spinal stenosis on MRI: A case control analysis within the wakayama spine study",
abstract = "Background: To explore the association of MRI-diagnosed severe lumbar spinal stenosis with occupation. Methods: Occupational data were collected by questionnaire and all participants underwent spine MRI scans using the same protocol. Central lumbar spinal stenosis (LSS) was graded qualitatively. Those with severe LSS (>two-thirds narrowing) were compared with the controls with lesser degrees of stenosis or no stenosis. Results: Data were available for 722 subjects, mean age 70.1 years. 239 (33%) cases with severe LSS were identified. Factory/construction workers had an almost four-fold increased risk of severe LSS after adjustment for age, sex, smoking, and walking speed amongst those aged <75 years (OR 3.97, 95%CI 1.46-10.85). Severe LSS was also associated with squatting ≥1 h/day (OR 1.76, 95%CI 1.01-3.07) but this association became non-significant after adjustment. Conclusion: Further research is needed but this study adds more evidence that occupational factors are associated with an increased risk and/or severity of degenerative disease of the lumbar spine.",
keywords = "factory and construction workers, Lumbar spinal stenosis (LSS), MRI, occupation, occupational exposures",
author = "Yuyu Ishimoto and Cyrus Cooper and Georgia Ntani and Hiroshi Yamada and Hiroshi Hashizume and Keiji Nagata and Shigeyuki Muraki and Sakae Tanaka and Noriko Yoshimura and Munehito Yoshida and Karen Walker-Bone",
note = "Funding Information: Grant sponsor: Grants-in-Aid for Scientific Research; Grant number: B20390182, B23390357, C20591737, C20591774 and C22591639. Grant sponsor: Young Scientists: Grant number: A18689031. Grant sponsor: Exploratory Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology; Grant number: 19659305. Grant sponsor: Grants-in-Aid from the Ministry of Health, Labour and Welfare: Grant number: H17-Men-eki-009, H18-Choujyu-037, and H20-Choujyu-009. Grant sponsor: Research Aid from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research): Grant number:2006–1 and 2010-2. Grant sponsor: A grant from the Japanese Orthopaedics and Traumatology Foundation, Inc.; Grant number: 166. Grant sponsor: the 2012 Wakayama Medical Award for Young Researchers. Grant sponsor: Grant-in-Aid for the Promotion of joint International Funding Information: Grant-in-Aid for the Promotion of joint International Research from Japan Society for the Promotion of Science, Grant number: 15KK0316; Grants-in-Aid for Scientific Research, Grant numbers: B20390182, B23390357, C20591737, C20591774 C22591639; Young Scientists, Grant number: A18689031; Exploratory Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology, Grant number: 19659305; Grants-in-Aid from the Ministry of Health, Labour and Welfare, Grant numbers: H17-Men-eki-009, H18-Choujyu-037, H20-Choujyu-009; Research Aid from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research), Grant numbers: 2006–1, 2010-2; A grant from the Japanese Orthopaedics and Traumatology Foundation, Inc., Grant number: 166; The 2012 Wakayama Funding Information: Grant sponsor: Grants-in-Aid for Scientific Research; Grant number: B20390182, B23390357, C20591737, C20591774 and C22591639. Grant sponsor: Young Scientists: Grant number: A18689031. Grant sponsor: Exploratory Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology; Grant number: 19659305. Grant sponsor: Grants-in-Aid from the Ministry of Health, Labour and Welfare: Grant number: H17-Men-eki-009, H18-Choujyu-037, and H20-Choujyu-009. Grant sponsor: Research Aid from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research): Grant number:2006?1 and 2010-2. Grant sponsor: A grant from the Japanese Orthopaedics and Traumatology Foundation, Inc.; Grant number: 166. Grant sponsor: the 2012 Wakayama Medical Award for Young Researchers. Grant sponsor: Grant-in-Aid for the Promotion of joint International Research from Japan Society for the Promotion of Science; Grant number:15KK0316. The sponsors had no role in study design, data collection, data analysis, data interpretation, or in the writing of the report. The authors wish to thank Mrs. Tomoko Takijiri and other members of the Public Office in Hidakagawa Town, and Mrs. Tamako Tsutsumi, Mrs. Kanami Maeda, and other members of the Public Office in Taiji Town, for their assistance in locating and scheduling participants for examinations. The corresponding author had full access to all the data and had the final decision to submit for publication. This study was performed in Hidakagawa Clinic and the center of Taijicho Tamokuteki Center, Wakayama, Japan. All participants provided written informed consent, and the study was conducted with the approval of ethical committees of the University of Tokyo and the Tokyo Metropolitan Institute of Gerontology (no.5). The authors declare no conflicts of interest. Rodney Ehrlich declares that he has no conflict of interest in the review and publication decision regarding this article. Funding Information: Medical Award for Young Researchers; Grant-in-Aid for the Promotion of joint International Research from Japan Society for the Promotion of Science, Grant number: 15KK0316 Publisher Copyright: {\textcopyright} 2019 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.",
year = "2019",
month = may,
doi = "10.1002/ajim.22957",
language = "English",
volume = "62",
pages = "430--438",
journal = "American Journal of Industrial Medicine",
issn = "0271-3586",
publisher = "John Wiley & Sons",
number = "5",
}
