Factors Responsible for Obesity-Related Hypertension

Kyungjoon Lim, Kristy L. Jackson, Yusuke Sata, Geoffrey A. Head

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Purpose of Review: The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs such as the kidney. Recent Findings: There is now convincing evidence from animal studies that major signals such as leptin and insulin have a sympathoexcitatory action in the hypothalamus to cause hypertension. Recent studies suggest that this may involve ‘neural plasticity’ within hypothalamic signalling driven by central actions of leptin mediated via activation of melanocortin receptor signalling and activation of brain neurotrophic factors. Summary: This review describes the evidence to support the contribution of the SNS to obesity related hypertension and the major metabolic and adipokine signals.

Original languageEnglish
Article number53
Number of pages10
JournalCurrent Hypertension Reports
Volume19
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Aversive stress
  • Blood pressure
  • Central nervous system
  • High fat diet
  • Hypertension
  • Hypothalamus
  • Insulin
  • Leptin
  • Obesity
  • Sympathetic nervous system

Cite this

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abstract = "Purpose of Review: The major health issue of being overweight or obese relates to the development of hypertension, insulin resistance and diabetic complications. One of the major underlying factors influencing the elevated blood pressure in obesity is increased activity of the sympathetic nerves to particular organs such as the kidney. Recent Findings: There is now convincing evidence from animal studies that major signals such as leptin and insulin have a sympathoexcitatory action in the hypothalamus to cause hypertension. Recent studies suggest that this may involve ‘neural plasticity’ within hypothalamic signalling driven by central actions of leptin mediated via activation of melanocortin receptor signalling and activation of brain neurotrophic factors. Summary: This review describes the evidence to support the contribution of the SNS to obesity related hypertension and the major metabolic and adipokine signals.",
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Factors Responsible for Obesity-Related Hypertension. / Lim, Kyungjoon; Jackson, Kristy L.; Sata, Yusuke; Head, Geoffrey A.

In: Current Hypertension Reports, Vol. 19, No. 7, 53, 01.07.2017.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Lim, Kyungjoon

AU - Jackson, Kristy L.

AU - Sata, Yusuke

AU - Head, Geoffrey A.

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KW - Hypothalamus

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KW - Leptin

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