Prosthetic joint infection (PJI) is associated with significant costs to the healthcare system. Current literature examines the cost of specific treatment modalities without assessing other cost drivers for PJI. Aims: To examine the overall cost of the treatment of PJI and to identify factors associated with management costs. Methods: The costs of treatment of prosthetic joint infections were examined in 139 patients across 10 hospitals over a 3-year period (January 2006 to December 2008). Cost calculations included hospitalization costs, surgical costs, hospital-in-the-home costs and antibiotic therapy costs. Negative binomial regression analysis was performed to model factors associated with total cost. Findings: The median cost of treating prosthetic joint infection per patient was Australian 34,800 (interquartile range: 20,305, 56,929). The following factors were associated with increased treatment costs: septic revision arthroplasty (67 increase in treatment cost; P=0.02), hypotension at presentation (70 increase; P=0.03), polymicrobial infections (41 increase; P=0.009), surgical treatment with one-stage exchange (100 increase; P=0.002) or resection arthroplasty (48 increase; P=0.001) were independently associated with increased treatment costs. Culture-negative prosthetic joint infections were associated with decreased costs (29 decrease in treatment cost; P=0.047). Treatment failure was associated with 156 increase in treatment costs. Conclusions: This study identifies clinically important factors influencing treatment costs that may be of relevance to policy-makers, particularly in the setting of hospital reimbursement and guiding future research into cost-effective preventive strategies.
- Prosthetic joint infection
Peel, T. N., Cheng, A. C., Lorenzo, Y. P., Kong, D. C. M., Buising, K. L., & Choong, P. F. M. (2013). Factors influencing the cost of prosthetic joint infection treatment. Journal of Hospital Infection, 85(3), 213 - 219. https://doi.org/10.1016/j.jhin.2013.07.012