Factors influencing detector matching in multidetector SEC: Solvent and concentration effects

Michael D. Zammit, Thomas P. Davis, Kevin G. Suddaby

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

A study has been conducted on the origin of the molecular weight (MWT) dependence of the apparent interdetector-delay (IDD) in multidetector size exclusion chromatography (SEC). The IDD-MWT relationship proved to be independent of polymer concentration (for a given molecular weight). In contrast, the IDD-MWT relationship was found to be influenced by the polymer-solvent interaction, as shown by SEC experiments on polystyrene in a mixed tetrahydrofuran-water eluent. Confirmation of this discovery was provided by measured variations in the IDD-MWT relationship for polystyrene and poly(methyl methacrylate) in THF eluent. Possible reasons for the strong influence of the polymer-solvent interaction on the IDD are discussed in the paper.

Original languageEnglish
Pages (from-to)5789-5798
Number of pages10
JournalPolymer
Volume39
Issue number23
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Keywords

  • Dead time
  • Interdetector-delay
  • Poly(styrene)

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