Factors Affecting Vitamin D Status in Infants

Charles Fink, Rachel L. Peters, Jennifer Koplin, Justin Brown, Katrina J Allen

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Vitamin D is critical to children’s skeletal development and health. Despite this, the factors which determine vitamin D concentrations during infancy remain incompletely understood. This article reviews the literature assessing the factors which can affect vitamin D status in infancy, including antenatal and postnatal vitamin D supplementation. Observational data supports that dietary intake of vitamin D, UV exposure, and geographic factors contribute significantly to infants’ vitamin D status, but the relationship is unclear regarding genetic variation, ethnicity, and maternal vitamin D status. Randomised controlled trials have compared higher versus lower doses of infant vitamin D supplementation, but no studies have compared infant vitamin D supplementation to placebo and eliminated external sources of vitamin D to fully quantify its effect on vitamin D status. Knowledge gaps remain regarding the factors associated with optimal vitamin D concentrations in infants—including key factors such as ethnicity and genetic variation—and further studies are needed.
Original languageEnglish
Article number7
Number of pages13
JournalChildren
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2019

Cite this

Fink, C., Peters, R. L., Koplin, J., Brown, J., & Allen, K. J. (2019). Factors Affecting Vitamin D Status in Infants. Children , 6(1), [7]. https://doi.org/10.3390/children6010007