TY - JOUR
T1 - Factors affecting use of magnesium sulphate for pre-eclampsia or eclampsia
T2 - a qualitative evidence synthesis
AU - Eddy, K. E.
AU - Vogel, J. P.
AU - Zahroh, R. I.
AU - Bohren, M. A.
N1 - Funding Information:
We would like to acknowledge the support from our institutions in facilitating the completion of this work. RIZ is sponsored by an Australian Awards Scholarship (ST000SSF2) for her master's education, funded by the Australian Department of Foreign Affairs and Trade (DFAT). MAB's time is supported by an Australian Research Council Discovery Early Career Researcher Award (DE200100264) and a Dame Kate Campbell Fellowship (University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences). JPV is supported by a National Health and Medical Research Council Investigator Grant (34520111).
Funding Information:
The authors received no funding for this work, which was completed as part of KEE's MPH at University of Melbourne School of Population and Global Health. We would like to acknowledge the support from our institutions in facilitating the completion of this work. RIZ is sponsored by an Australian Awards Scholarship (ST000SSF2) for her master's education, funded by the Australian Department of Foreign Affairs and Trade (DFAT). MAB's time is supported by an Australian Research Council Discovery Early Career Researcher Award (DE200100264) and a Dame Kate Campbell Fellowship (University of Melbourne Faculty of Medicine, Dentistry, and Health Sciences). JPV is supported by a National Health and Medical Research Council Investigator Grant (1194248).
Publisher Copyright:
© 2021 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
PY - 2022/2
Y1 - 2022/2
N2 - Background: Hypertensive disorders account for 14% of global maternal deaths. Magnesium sulphate (MgSO4) is recommended for prevention and treatment of pre-eclampsia/eclampsia. However, MgSO4 remains underused, particularly in low- and middle-income countries (LMICs). Objective: This qualitative evidence synthesis explores perceptions and experiences of healthcare providers, administrators and policy-makers regarding factors affecting use of MgSO4 to prevent or treat pre-eclampsia/eclampsia. Search strategy: We searched MEDLINE, EMBASE, Emcare, CINAHL, Global Health and Global Index Medicus, and grey literature for studies published between January 1995 and June 2021. Selection criteria: Primary qualitative and mixed-methods studies on factors affecting use of MgSO4 in healthcare settings, from the perspectives of healthcare providers, administrators and policy-makers, were eligible for inclusion. Data collection and analysis: We applied a thematic synthesis approach to analysis, using COM-B behaviour change theory to map factors affecting appropriate use of MgSO4. Main results: We included 22 studies, predominantly from LMICs. Key themes included provider competence and confidence administering MgSO4 (attitudes and beliefs, complexities of administering, knowledge and experience), capability of health systems to ensure MgSO4 availability at point of use (availability, resourcing and pathways to care) and knowledge translation (dissemination of research and recommendations). Within each COM-B domain, we mapped facilitators and barriers to physical and psychological capability, physical and social opportunity, and how the interplay between these domains influences motivation. Conclusions: These findings can inform policy and guideline development and improve implementation of MgSO4 in clinical care. Such action is needed to ensure this life-saving treatment is widely available and appropriately used. Tweetable abstract: Global qualitative review identifies factors affecting underutilisation of MgSO4 for pre-eclampsia and eclampsia.
AB - Background: Hypertensive disorders account for 14% of global maternal deaths. Magnesium sulphate (MgSO4) is recommended for prevention and treatment of pre-eclampsia/eclampsia. However, MgSO4 remains underused, particularly in low- and middle-income countries (LMICs). Objective: This qualitative evidence synthesis explores perceptions and experiences of healthcare providers, administrators and policy-makers regarding factors affecting use of MgSO4 to prevent or treat pre-eclampsia/eclampsia. Search strategy: We searched MEDLINE, EMBASE, Emcare, CINAHL, Global Health and Global Index Medicus, and grey literature for studies published between January 1995 and June 2021. Selection criteria: Primary qualitative and mixed-methods studies on factors affecting use of MgSO4 in healthcare settings, from the perspectives of healthcare providers, administrators and policy-makers, were eligible for inclusion. Data collection and analysis: We applied a thematic synthesis approach to analysis, using COM-B behaviour change theory to map factors affecting appropriate use of MgSO4. Main results: We included 22 studies, predominantly from LMICs. Key themes included provider competence and confidence administering MgSO4 (attitudes and beliefs, complexities of administering, knowledge and experience), capability of health systems to ensure MgSO4 availability at point of use (availability, resourcing and pathways to care) and knowledge translation (dissemination of research and recommendations). Within each COM-B domain, we mapped facilitators and barriers to physical and psychological capability, physical and social opportunity, and how the interplay between these domains influences motivation. Conclusions: These findings can inform policy and guideline development and improve implementation of MgSO4 in clinical care. Such action is needed to ensure this life-saving treatment is widely available and appropriately used. Tweetable abstract: Global qualitative review identifies factors affecting underutilisation of MgSO4 for pre-eclampsia and eclampsia.
UR - https://www.scopus.com/pages/publications/85116365200
U2 - 10.1111/1471-0528.16913
DO - 10.1111/1471-0528.16913
M3 - Review Article
C2 - 34520111
AN - SCOPUS:85116365200
SN - 1470-0328
VL - 129
SP - 379
EP - 391
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 3
ER -