Factor XIII assays

Stephen Opat, Jenny Butler, Erica Malan, Elizabeth Mary Duncan, Huyen A Tran

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Abstract

Factor XIII (FXIII) deficiency is a rare cause of bleeding and pregnancy loss that is easily treated with plasma products. Reliable assays for FXIII are necessary not only for the diagnosis of deficiency state but also to guide prophylaxis and replacement therapy in patients during times of increased risk. Diagnostic tests for FXIII activity whilst not technically demanding have a number of pitfalls including limited sensitivity and overestimation of activity at the lower end. Despite these shortcomings the performance of these assays is adequate for the diagnosis and management of the majority of patients with clinically significant deficiency. ? 2013 Springer Science+Business Media New York.
Original languageEnglish
Title of host publicationHaemostasis: Methods and Protocols
EditorsPaul Monagle
Place of PublicationUnited States
PublisherHumana Press
Pages171 - 180
Number of pages10
Volume992
ISBN (Print)9781627033398
DOIs
Publication statusPublished - 2013

Cite this

Opat, S., Butler, J., Malan, E., Duncan, E. M., & Tran, H. A. (2013). Factor XIII assays. In P. Monagle (Ed.), Haemostasis: Methods and Protocols (Vol. 992, pp. 171 - 180). United States: Humana Press. https://doi.org/10.1007/978-1-62703-339-8_13
Opat, Stephen ; Butler, Jenny ; Malan, Erica ; Duncan, Elizabeth Mary ; Tran, Huyen A. / Factor XIII assays. Haemostasis: Methods and Protocols. editor / Paul Monagle. Vol. 992 United States : Humana Press, 2013. pp. 171 - 180
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Opat, S, Butler, J, Malan, E, Duncan, EM & Tran, HA 2013, Factor XIII assays. in P Monagle (ed.), Haemostasis: Methods and Protocols. vol. 992, Humana Press, United States, pp. 171 - 180. https://doi.org/10.1007/978-1-62703-339-8_13

Factor XIII assays. / Opat, Stephen; Butler, Jenny; Malan, Erica; Duncan, Elizabeth Mary; Tran, Huyen A.

Haemostasis: Methods and Protocols. ed. / Paul Monagle. Vol. 992 United States : Humana Press, 2013. p. 171 - 180.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

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AU - Opat, Stephen

AU - Butler, Jenny

AU - Malan, Erica

AU - Duncan, Elizabeth Mary

AU - Tran, Huyen A

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N2 - Factor XIII (FXIII) deficiency is a rare cause of bleeding and pregnancy loss that is easily treated with plasma products. Reliable assays for FXIII are necessary not only for the diagnosis of deficiency state but also to guide prophylaxis and replacement therapy in patients during times of increased risk. Diagnostic tests for FXIII activity whilst not technically demanding have a number of pitfalls including limited sensitivity and overestimation of activity at the lower end. Despite these shortcomings the performance of these assays is adequate for the diagnosis and management of the majority of patients with clinically significant deficiency. ? 2013 Springer Science+Business Media New York.

AB - Factor XIII (FXIII) deficiency is a rare cause of bleeding and pregnancy loss that is easily treated with plasma products. Reliable assays for FXIII are necessary not only for the diagnosis of deficiency state but also to guide prophylaxis and replacement therapy in patients during times of increased risk. Diagnostic tests for FXIII activity whilst not technically demanding have a number of pitfalls including limited sensitivity and overestimation of activity at the lower end. Despite these shortcomings the performance of these assays is adequate for the diagnosis and management of the majority of patients with clinically significant deficiency. ? 2013 Springer Science+Business Media New York.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23546713

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BT - Haemostasis: Methods and Protocols

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Opat S, Butler J, Malan E, Duncan EM, Tran HA. Factor XIII assays. In Monagle P, editor, Haemostasis: Methods and Protocols. Vol. 992. United States: Humana Press. 2013. p. 171 - 180 https://doi.org/10.1007/978-1-62703-339-8_13