Facilitating a culture of responsible and effective sharing of cancer genome data

Lillian L. Siu; Mark Lawler; David Haussler; Bartha Maria Knoppers; Jeremy Lewin; Daniel J. Vis; Rachel G. Liao; Fabrice Andre; Ian Banks; J. Carl Barrett; Carlos Caldas; Anamaria Aranha Camargo; Rebecca C. Fitzgerald; Mao Mao; John E. Mattison; William Pao; William R. Sellers; Patrick Sullivan; Bin Tean Teh; Robyn L. Ward; Jean Claude ZenKlusen; Charles L. Sawyers; Emile E. Voest

doi:10.1007/978-3-319-51358-4_12

Facilitating a culture of responsible and effective sharing of cancer genome data

Lillian L. Siu
, Mark Lawler
, David Haussler
, Bartha Maria Knoppers
, Jeremy Lewin
, Daniel J. Vis
, Rachel G. Liao
, Fabrice Andre
, Ian Banks
, J. Carl Barrett
, Carlos Caldas
, Anamaria Aranha Camargo
, Rebecca C. Fitzgerald
, Mao Mao
, John E. Mattison
, William Pao
, William R. Sellers
, Patrick Sullivan
, Bin Tean Teh
, Robyn L. Ward

Jean Claude ZenKlusen, Charles L. Sawyers, Emile E. Voest

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.

Original language	English
Title of host publication	Getting to Good
Subtitle of host publication	Research Integrity in the Biomedical Sciences
Editors	Arthur L. Caplan, Barbara K. Redman
Place of Publication	Cham Switzerland
Publisher	Springer
Pages	539-548
Number of pages	10
Edition	1st
ISBN (Electronic)	9783319513584
ISBN (Print)	9783319513577
DOIs	https://doi.org/10.1007/978-3-319-51358-4_12
Publication status	Published - 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1007/978-3-319-51358-4_12

Cite this

Siu, L. L., Lawler, M., Haussler, D., Knoppers, B. M., Lewin, J., Vis, D. J., Liao, R. G., Andre, F., Banks, I., Barrett, J. C., Caldas, C., Camargo, A. A., Fitzgerald, R. C., Mao, M., Mattison, J. E., Pao, W., Sellers, W. R., Sullivan, P., Teh, B. T., ... Voest, E. E. (2018). Facilitating a culture of responsible and effective sharing of cancer genome data. In A. L. Caplan, & B. K. Redman (Eds.), Getting to Good: Research Integrity in the Biomedical Sciences (1st ed., pp. 539-548). Springer. https://doi.org/10.1007/978-3-319-51358-4_12

@inbook{d234eff8bf89491b9295bd082b6a13d7,

title = "Facilitating a culture of responsible and effective sharing of cancer genome data",

abstract = "Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.",

author = "Siu, \{Lillian L.\} and Mark Lawler and David Haussler and Knoppers, \{Bartha Maria\} and Jeremy Lewin and Vis, \{Daniel J.\} and Liao, \{Rachel G.\} and Fabrice Andre and Ian Banks and Barrett, \{J. Carl\} and Carlos Caldas and Camargo, \{Anamaria Aranha\} and Fitzgerald, \{Rebecca C.\} and Mao Mao and Mattison, \{John E.\} and William Pao and Sellers, \{William R.\} and Patrick Sullivan and Teh, \{Bin Tean\} and Ward, \{Robyn L.\} and ZenKlusen, \{Jean Claude\} and Sawyers, \{Charles L.\} and Voest, \{Emile E.\}",

note = "Publisher Copyright: {\textcopyright} 2016, Nature Medicine.",

year = "2018",

doi = "10.1007/978-3-319-51358-4\_12",

language = "English",

isbn = "9783319513577",

pages = "539--548",

editor = "Caplan, \{Arthur L.\} and Redman, \{Barbara K.\}",

booktitle = "Getting to Good",

publisher = "Springer",

address = "Switzerland",

edition = "1st",

}

Siu, LL, Lawler, M, Haussler, D, Knoppers, BM, Lewin, J, Vis, DJ, Liao, RG, Andre, F, Banks, I, Barrett, JC, Caldas, C, Camargo, AA, Fitzgerald, RC, Mao, M, Mattison, JE, Pao, W, Sellers, WR, Sullivan, P, Teh, BT, Ward, RL, ZenKlusen, JC, Sawyers, CL & Voest, EE 2018, Facilitating a culture of responsible and effective sharing of cancer genome data. in AL Caplan & BK Redman (eds), Getting to Good: Research Integrity in the Biomedical Sciences. 1st edn, Springer, Cham Switzerland, pp. 539-548. https://doi.org/10.1007/978-3-319-51358-4_12

Facilitating a culture of responsible and effective sharing of cancer genome data. / Siu, Lillian L.; Lawler, Mark; Haussler, David et al.
Getting to Good: Research Integrity in the Biomedical Sciences. ed. / Arthur L. Caplan; Barbara K. Redman. 1st. ed. Cham Switzerland: Springer, 2018. p. 539-548.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

TY - CHAP

T1 - Facilitating a culture of responsible and effective sharing of cancer genome data

AU - Siu, Lillian L.

AU - Lawler, Mark

AU - Haussler, David

AU - Knoppers, Bartha Maria

AU - Lewin, Jeremy

AU - Vis, Daniel J.

AU - Liao, Rachel G.

AU - Andre, Fabrice

AU - Banks, Ian

AU - Barrett, J. Carl

AU - Caldas, Carlos

AU - Camargo, Anamaria Aranha

AU - Fitzgerald, Rebecca C.

AU - Mao, Mao

AU - Mattison, John E.

AU - Pao, William

AU - Sellers, William R.

AU - Sullivan, Patrick

AU - Teh, Bin Tean

AU - Ward, Robyn L.

AU - ZenKlusen, Jean Claude

AU - Sawyers, Charles L.

AU - Voest, Emile E.

PY - 2018

Y1 - 2018

N2 - Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.

AB - Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.

UR - https://www.scopus.com/pages/publications/85063362756

U2 - 10.1007/978-3-319-51358-4_12

DO - 10.1007/978-3-319-51358-4_12

M3 - Chapter (Book)

AN - SCOPUS:85063362756

SN - 9783319513577

SP - 539

EP - 548

BT - Getting to Good

A2 - Caplan, Arthur L.

A2 - Redman, Barbara K.

PB - Springer

CY - Cham Switzerland

ER -

Facilitating a culture of responsible and effective sharing of cancer genome data

Abstract

UN SDGs

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Research output

Facilitating a culture of responsible and effective sharing of cancer genome data

Cite this