Facile one-pot/one-step synthesis of heterotelechelic: N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers

Patrick A. J. M. de Jongh; Mechelle R. Bennett; Greg S. Sulley; Paul Wilson; Thomas P. Davis; David M. Haddleton; Kristian Kempe

doi:10.1039/c6py01553k

Facile one-pot/one-step synthesis of heterotelechelic: N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers

Patrick A. J. M. de Jongh, Mechelle R. Bennett, Greg S. Sulley, Paul Wilson, Thomas P. Davis, David M. Haddleton, Kristian Kempe

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.

Original language	English
Pages (from-to)	6703-6707
Number of pages	5
Journal	Polymer Chemistry
Volume	7
Issue number	44
DOIs	https://doi.org/10.1039/c6py01553k
Publication status	Published - 28 Nov 2016

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10.1039/c6py01553k

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Cite this

@article{e60d2b91aa1545f7b6b0cafced28229d,

title = "Facile one-pot/one-step synthesis of heterotelechelic: N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers",

abstract = "Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.",

author = "{de Jongh}, {Patrick A. J. M.} and Bennett, {Mechelle R.} and Sulley, {Greg S.} and Paul Wilson and Davis, {Thomas P.} and Haddleton, {David M.} and Kristian Kempe",

year = "2016",

month = nov,

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doi = "10.1039/c6py01553k",

language = "English",

volume = "7",

pages = "6703--6707",

journal = "Polymer Chemistry",

issn = "1759-9954",

publisher = "The Royal Society of Chemistry",

number = "44",

}

Facile one-pot/one-step synthesis of heterotelechelic : N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers. / de Jongh, Patrick A. J. M.; Bennett, Mechelle R.; Sulley, Greg S.; Wilson, Paul; Davis, Thomas P.; Haddleton, David M.; Kempe, Kristian.

In: Polymer Chemistry, Vol. 7, No. 44, 28.11.2016, p. 6703-6707.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Facile one-pot/one-step synthesis of heterotelechelic

T2 - N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers

AU - de Jongh, Patrick A. J. M.

AU - Bennett, Mechelle R.

AU - Sulley, Greg S.

AU - Wilson, Paul

AU - Davis, Thomas P.

AU - Haddleton, David M.

AU - Kempe, Kristian

PY - 2016/11/28

Y1 - 2016/11/28

N2 - Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.

AB - Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.

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