Facile one-pot/one-step synthesis of heterotelechelic

N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers

Patrick A. J. M. de Jongh, Mechelle R. Bennett, Greg S. Sulley, Paul Wilson, Thomas P. Davis, David M. Haddleton, Kristian Kempe

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.

Original languageEnglish
Pages (from-to)6703-6707
Number of pages5
JournalPolymer Chemistry
Volume7
Issue number44
DOIs
Publication statusPublished - 28 Nov 2016

Cite this

de Jongh, Patrick A. J. M. ; Bennett, Mechelle R. ; Sulley, Greg S. ; Wilson, Paul ; Davis, Thomas P. ; Haddleton, David M. ; Kempe, Kristian. / Facile one-pot/one-step synthesis of heterotelechelic : N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers. In: Polymer Chemistry. 2016 ; Vol. 7, No. 44. pp. 6703-6707.
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abstract = "Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.",
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Facile one-pot/one-step synthesis of heterotelechelic : N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers. / de Jongh, Patrick A. J. M.; Bennett, Mechelle R.; Sulley, Greg S.; Wilson, Paul; Davis, Thomas P.; Haddleton, David M.; Kempe, Kristian.

In: Polymer Chemistry, Vol. 7, No. 44, 28.11.2016, p. 6703-6707.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Bennett, Mechelle R.

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AU - Kempe, Kristian

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AB - Optimised monomer feed ratios in the spontaneous zwitterionic copolymerisation (SZWIP) of 2-oxazolines and acrylic acid enable the one-step synthesis of heterotelechelic α-acrylate, ω-carboxylic acid N-acylated poly(aminoester) macromonomers. Subsequent redox-initiated RAFT polymerisation at ambient temperature leads to comb polymers containing quantitative terminal side chain carboxylic acids, which allow efficient 'grafting-onto' using conventional peptide coupling strategies.

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