TY - JOUR
T1 - Fabrication of poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded doxorubicin implants and in vitro characterization
AU - Sreeharsha, Nagaraja
AU - Hiremath, Jagadeesh G.
AU - Al-Dhubiab, Bandar E.
AU - Meravanige, Girish
AU - Karnati, Ranjith Kumar
AU - Attimarad, Mahesh
AU - Nair, Anroop B.
AU - Venugopal, Katharigatta N.
AU - Morsy, Mohamed A.
AU - Pottathil, Shinu
AU - Khan, Saleemmulla
AU - Molugulu, Nagashekhara
N1 - Funding Information:
The authors acknowledge the Deanship of Scientific Research at King Faisal University for providing financial support under the Nasher Track (grant number: 186248).
Publisher Copyright:
© Association of Pharmaceutical Teachers of India. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SA-RA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.
AB - Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SA-RA] 70:30 w/w PSRA 7/3) polymer. Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated. Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant. Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.
KW - Biodegradable polymer
KW - Cylinder
KW - Doxorubicin
KW - In vitro
KW - Poly(sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w
KW - β-cyclodextrin
UR - https://www.scopus.com/pages/publications/85090369038
U2 - 10.5530/ijper.54.3.135
DO - 10.5530/ijper.54.3.135
M3 - Article
AN - SCOPUS:85090369038
SN - 0019-5464
VL - 54
SP - 826
EP - 834
JO - Indian Journal of Pharmaceutical Education and Research
JF - Indian Journal of Pharmaceutical Education and Research
IS - 3
ER -