Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

C. Szydzik, B. Niego, G. Dalzell, M. Knoerzer, F. Ball, W. S. Nesbitt, R. L. Medcalf, K. Khoshmanesh, A. Mitchell

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels, and fabrication of elastomeric microfluidic valves. This technique simplifies multi-layer microfluidic device fabrication, while significantly increasing device functionality. We demonstrate functional component integration through robust encapsulation of porous polyester membranes, in the context of an in vitro research platform intended to facilitate Blood Brain Barrier (BBB) research. We also demonstrate the fabrication of normally-closed, pneumatically actuated elastomer valves, integrated using the same one-step process. These valves are demonstrated in the context of variable flow resistors used to modulate flow in a pressure driven system.

Original languageEnglish
Pages (from-to)87988-87994
Number of pages7
JournalRSC Advances
Volume6
Issue number91
DOIs
Publication statusPublished - 2016

Cite this

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title = "Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding",
abstract = "We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels, and fabrication of elastomeric microfluidic valves. This technique simplifies multi-layer microfluidic device fabrication, while significantly increasing device functionality. We demonstrate functional component integration through robust encapsulation of porous polyester membranes, in the context of an in vitro research platform intended to facilitate Blood Brain Barrier (BBB) research. We also demonstrate the fabrication of normally-closed, pneumatically actuated elastomer valves, integrated using the same one-step process. These valves are demonstrated in the context of variable flow resistors used to modulate flow in a pressure driven system.",
author = "C. Szydzik and B. Niego and G. Dalzell and M. Knoerzer and F. Ball and Nesbitt, {W. S.} and Medcalf, {R. L.} and K. Khoshmanesh and A. Mitchell",
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language = "English",
volume = "6",
pages = "87988--87994",
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publisher = "Royal Society of Chemistry (RSC)",
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Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding. / Szydzik, C.; Niego, B.; Dalzell, G.; Knoerzer, M.; Ball, F.; Nesbitt, W. S.; Medcalf, R. L.; Khoshmanesh, K.; Mitchell, A.

In: RSC Advances, Vol. 6, No. 91, 2016, p. 87988-87994.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

AU - Szydzik, C.

AU - Niego, B.

AU - Dalzell, G.

AU - Knoerzer, M.

AU - Ball, F.

AU - Nesbitt, W. S.

AU - Medcalf, R. L.

AU - Khoshmanesh, K.

AU - Mitchell, A.

PY - 2016

Y1 - 2016

N2 - We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels, and fabrication of elastomeric microfluidic valves. This technique simplifies multi-layer microfluidic device fabrication, while significantly increasing device functionality. We demonstrate functional component integration through robust encapsulation of porous polyester membranes, in the context of an in vitro research platform intended to facilitate Blood Brain Barrier (BBB) research. We also demonstrate the fabrication of normally-closed, pneumatically actuated elastomer valves, integrated using the same one-step process. These valves are demonstrated in the context of variable flow resistors used to modulate flow in a pressure driven system.

AB - We report a novel injection moulding technique for fabrication of complex multi-layer microfluidic structures, allowing one-step robust integration of functional components with microfluidic channels, and fabrication of elastomeric microfluidic valves. This technique simplifies multi-layer microfluidic device fabrication, while significantly increasing device functionality. We demonstrate functional component integration through robust encapsulation of porous polyester membranes, in the context of an in vitro research platform intended to facilitate Blood Brain Barrier (BBB) research. We also demonstrate the fabrication of normally-closed, pneumatically actuated elastomer valves, integrated using the same one-step process. These valves are demonstrated in the context of variable flow resistors used to modulate flow in a pressure driven system.

UR - http://www.scopus.com/inward/record.url?scp=84988421052&partnerID=8YFLogxK

U2 - 10.1039/c6ra20688c

DO - 10.1039/c6ra20688c

M3 - Article

VL - 6

SP - 87988

EP - 87994

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 91

ER -