Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system

Simon J. Leigh; Hamish T.J. Gilbert; Ian A. Barker; Jan M. Becker; Stephen M. Richardson; Judith A. Hoyland; James A. Covington; Andrew P. Dove

doi:10.1021/bm3015736

Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system

Simon J. Leigh, Hamish T.J. Gilbert, Ian A. Barker, Jan M. Becker, Stephen M. Richardson, Judith A. Hoyland, James A. Covington, Andrew P. Dove

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

Original language	English
Pages (from-to)	186-192
Number of pages	7
Journal	Biomacromolecules
Volume	14
Issue number	1
DOIs	https://doi.org/10.1021/bm3015736
Publication status	Published - 14 Jan 2013
Externally published	Yes

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title = "Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system",

abstract = "A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.",

author = "Leigh, {Simon J.} and Gilbert, {Hamish T.J.} and Barker, {Ian A.} and Becker, {Jan M.} and Richardson, {Stephen M.} and Hoyland, {Judith A.} and Covington, {James A.} and Dove, {Andrew P.}",

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doi = "10.1021/bm3015736",

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AU - Leigh, Simon J.

AU - Gilbert, Hamish T.J.

AU - Barker, Ian A.

AU - Becker, Jan M.

AU - Richardson, Stephen M.

AU - Hoyland, Judith A.

AU - Covington, James A.

AU - Dove, Andrew P.

PY - 2013/1/14

Y1 - 2013/1/14

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AB - A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

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Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system

Abstract

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