Fabrication of 3-dimensional cellular constructs via microstereolithography using a simple, three-component, poly(ethylene glycol) acrylate-based system

Simon J. Leigh, Hamish T.J. Gilbert, Ian A. Barker, Jan M. Becker, Stephen M. Richardson, Judith A. Hoyland, James A. Covington, Andrew P. Dove

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

A novel method for the production of inhibitor- and solvent-free resins suitable for three-dimensional (3D) microstereolithography is reported. Using an exemplar poly(ethylene glycol)-based resin, the control of features in the X, Y, and Z planes is demonstrated such that complex structures can be manufactured. Human mesenchymal stem cells cultured on the manufactured scaffolds remained viable during the 7 day assessment period, with proliferation rates comparable to those observed on tissue culture polystyrene. These data suggest that this novel, yet simple, method is suitable for the production of 3D scaffolds for tissue engineering and regenerative medicine applications.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalBiomacromolecules
Volume14
Issue number1
DOIs
Publication statusPublished - 14 Jan 2013
Externally publishedYes

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