Fabrication, mechanical properties and cytocompatibility of elastomeric nanofibrous mats of poly(glycerol sebacate)

Bing Xu, Yuan Li, Chenghao Zhu, Wayne D. Cook, John S. Forsythe, Qizhi Chen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

It is often difficult to achieve a satisfactory balance of compliance and biocompatibility simultaneously in a pure elastomeric material. In this work, we successfully fabricated an elastomeric fibrous mat from poly(glycerol sebacate) (PGS) with a 2:3 mol ratio of glycerol to sebacic acid, using the core/shell electrospinning technology of poly(vinyl alcohol) (PVA) as a temporary shell and PGS prepolymer as the core. After the core/shell electrospinning, the PGS core was crosslinked by thermal treatment and the PVA shell was partially removed by dissolution in water. The resulting PGS fibre mat was as soft as many soft tissues (e.g., muscle), and demonstrated nonlinear, J-shaped stress–strain curves (the slope continuously increased with increasing strain) when saturated with water. In vitro evaluations showed that the spun PGS2:3 mat had good cytocompatibility, better than the culture medium and the control material, PLLA fibrous mat. Hence, the newly developed electrospun PGS2:3 fibre mats may offer a much better choice of scaffolds than existing products for engineering of soft tissues working in dynamic conditions.
Original languageEnglish
Pages (from-to)79 - 92
Number of pages14
JournalEuropean Polymer Journal
Volume64
DOIs
Publication statusPublished - 2015

Cite this

Xu, Bing ; Li, Yuan ; Zhu, Chenghao ; Cook, Wayne D. ; Forsythe, John S. ; Chen, Qizhi. / Fabrication, mechanical properties and cytocompatibility of elastomeric nanofibrous mats of poly(glycerol sebacate). In: European Polymer Journal. 2015 ; Vol. 64. pp. 79 - 92.
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abstract = "It is often difficult to achieve a satisfactory balance of compliance and biocompatibility simultaneously in a pure elastomeric material. In this work, we successfully fabricated an elastomeric fibrous mat from poly(glycerol sebacate) (PGS) with a 2:3 mol ratio of glycerol to sebacic acid, using the core/shell electrospinning technology of poly(vinyl alcohol) (PVA) as a temporary shell and PGS prepolymer as the core. After the core/shell electrospinning, the PGS core was crosslinked by thermal treatment and the PVA shell was partially removed by dissolution in water. The resulting PGS fibre mat was as soft as many soft tissues (e.g., muscle), and demonstrated nonlinear, J-shaped stress–strain curves (the slope continuously increased with increasing strain) when saturated with water. In vitro evaluations showed that the spun PGS2:3 mat had good cytocompatibility, better than the culture medium and the control material, PLLA fibrous mat. Hence, the newly developed electrospun PGS2:3 fibre mats may offer a much better choice of scaffolds than existing products for engineering of soft tissues working in dynamic conditions.",
author = "Bing Xu and Yuan Li and Chenghao Zhu and Cook, {Wayne D.} and Forsythe, {John S.} and Qizhi Chen",
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Fabrication, mechanical properties and cytocompatibility of elastomeric nanofibrous mats of poly(glycerol sebacate). / Xu, Bing; Li, Yuan; Zhu, Chenghao; Cook, Wayne D.; Forsythe, John S.; Chen, Qizhi.

In: European Polymer Journal, Vol. 64, 2015, p. 79 - 92.

Research output: Contribution to journalArticleResearchpeer-review

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