Extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue of the gallbladder

Sally K. Ng, Krishna Epari, Sarah Parsons, Andrew Wei, Simon W. Banting

Research output: Contribution to journalArticleResearchpeer-review


Mucosa-associated lymphoid tissue (MALT) lymphoma of the gallbladder is rare with six cases reported in the English published reports. Most patients present with symptoms consistent with cholecystitis. We describe a case of extranodal marginal zone B-cell lymphoma of MALT of the gallbladder in a 60-year-old woman who presented with abnormal liver function tests and subsequent finding of gallbladder thickening on ultrasonography. Cholecystectomy revealed a chronically inflamed gallbladder with multiple gallstones. Histology revealed abnormal sheets of small B lymphoid cells which were CD 20 positive, consistent with a diagnosis of MALT lymphoma. The pathogenesis of MALT lymphoma in the gallbladder remains controversial. As the gallbladder does not normally contain lymphocytes, persistent lymphoid proliferation due to chronic Gram-negative infection may represent a critical step in the development and progression of MALT lymphoma. Cholecystectomy without adjuvant chemotherapy is the appropriate first line treatment if there is no other symptomatic disease.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalSurgical Practice
Issue number4
Publication statusPublished - 22 Oct 2008
Externally publishedYes


  • Gallbladder
  • Lymphoma
  • MALT

Cite this