Extracorporeal blood purification and organ support in the critically ill patient during covid-19 pandemic: expert review and recommendation

Claudio Ronco, Sean M. Bagshaw, Rinaldo Bellomo, William R. Clark, Faeq Husain-Syed, John A. Kellum, Zaccaria Ricci, Thomas Rimmelé, Thiago Reis, Marlies Ostermann

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. Based on pathophysiological derangements observed in COVID-19 patients, a rationale emerges for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ systems. In the absence of vaccines or direct therapy for COVID-19, extracorporeal therapies could represent an option to prevent organ failure and improve survival. The enormous demand in care for COVID-19 patients requires an immediate response from the scientific community. Thus, a detailed review of the available technology is provided by experts followed by a series of recommendation based on current experience and opinions, while waiting for generation of robust evidence from trials.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalBlood Purification
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

Keywords

  • Continuous renal replacement therapies
  • Cytokine removal
  • Extracorporeal organ support
  • Hemoadsorption
  • Hemoperfusion

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