AIM: A number of growth factors have been shown to induce proliferation of renal cell types in animal models of kidney disease. In vitro studies suggest that many such growth factors induce renal cell proliferation through the extracellular signal-regulated kinase (ERK) pathway. The aim of this study was to determine the functional role of ERK signalling in cell proliferation in the obstructed kidney.
Han, Y., Masaki, T., Hurst, L. A., Ikezumi, Y., Trzaskos, J. M., Atkins, R. C., & Nikolic-Paterson, D. J. (2008). Extracellular signal-regulated kinase-dependent interstitial macrophage proliferation in the obstructed mouse kidney. Nephrology, 13(5), 411 - 418. https://doi.org/10.1111/j.1440-1797.2008.00926.x