Extracellular signal-regulated kinase-dependent interstitial macrophage proliferation in the obstructed mouse kidney

Yingjie Han, Takao Masaki, Lynette A Hurst, Yohei Ikezumi, James M Trzaskos, Robert Charles Atkins, David J Nikolic-Paterson

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

AIM: A number of growth factors have been shown to induce proliferation of renal cell types in animal models of kidney disease. In vitro studies suggest that many such growth factors induce renal cell proliferation through the extracellular signal-regulated kinase (ERK) pathway. The aim of this study was to determine the functional role of ERK signalling in cell proliferation in the obstructed kidney.
Original languageEnglish
Pages (from-to)411 - 418
Number of pages8
JournalNephrology
Volume13
Issue number5
DOIs
Publication statusPublished - 2008

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