Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Jian Song; Zerina Lokmic; Tim Lämmermann; Julia Rolf; Chuan Wu; Xueli Zhang; Rupert Hallmann; Melanie Jane Hannocks; Nathalie Horn; Markus A. Ruegg; Arnoud Sonnenberg; Elisabeth Georges-Labouesse; Thomas H. Winkler; John F. Kearney; Susanna Cardell; Lydia Sorokin

doi:10.1073/pnas.1218131110

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Jian Song
, Zerina Lokmic
, Tim Lämmermann
, Julia Rolf
, Chuan Wu
, Xueli Zhang
, Rupert Hallmann
, Melanie Jane Hannocks
, Nathalie Horn
, Markus A. Ruegg
, Arnoud Sonnenberg
, Elisabeth Georges-Labouesse
, Thomas H. Winkler
, John F. Kearney
, Susanna Cardell
, Lydia Sorokin

Research output: Contribution to journal › Article › Research › peer-review

81 Citations (Scopus)

Abstract

We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

Original language	English
Pages (from-to)	E2915-E2924
Number of pages	10
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	110
Issue number	31
DOIs	https://doi.org/10.1073/pnas.1218131110
Publication status	Published - 30 Jul 2013
Externally published	Yes

Keywords

B-cell development
Immunology

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10.1073/pnas.1218131110

Cite this

Song, J., Lokmic, Z., Lämmermann, T., Rolf, J., Wu, C., Zhang, X., Hallmann, R., Hannocks, M. J., Horn, N., Ruegg, M. A., Sonnenberg, A., Georges-Labouesse, E., Winkler, T. H., Kearney, J. F., Cardell, S., & Sorokin, L. (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110(31), E2915-E2924. https://doi.org/10.1073/pnas.1218131110

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title = "Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival",

abstract = "We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.",

keywords = "B-cell development, Immunology",

author = "Jian Song and Zerina Lokmic and Tim L{\"a}mmermann and Julia Rolf and Chuan Wu and Xueli Zhang and Rupert Hallmann and Hannocks, \{Melanie Jane\} and Nathalie Horn and Ruegg, \{Markus A.\} and Arnoud Sonnenberg and Elisabeth Georges-Labouesse and Winkler, \{Thomas H.\} and Kearney, \{John F.\} and Susanna Cardell and Lydia Sorokin",

year = "2013",

month = jul,

day = "30",

doi = "10.1073/pnas.1218131110",

language = "English",

volume = "110",

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Song, J, Lokmic, Z, Lämmermann, T, Rolf, J, Wu, C, Zhang, X, Hallmann, R, Hannocks, MJ, Horn, N, Ruegg, MA, Sonnenberg, A, Georges-Labouesse, E, Winkler, TH, Kearney, JF, Cardell, S & Sorokin, L 2013, 'Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 31, pp. E2915-E2924. https://doi.org/10.1073/pnas.1218131110

TY - JOUR

T1 - Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

AU - Song, Jian

AU - Lokmic, Zerina

AU - Lämmermann, Tim

AU - Rolf, Julia

AU - Wu, Chuan

AU - Zhang, Xueli

AU - Hallmann, Rupert

AU - Hannocks, Melanie Jane

AU - Horn, Nathalie

AU - Ruegg, Markus A.

AU - Sonnenberg, Arnoud

AU - Georges-Labouesse, Elisabeth

AU - Winkler, Thomas H.

AU - Kearney, John F.

AU - Cardell, Susanna

AU - Sorokin, Lydia

PY - 2013/7/30

Y1 - 2013/7/30

N2 - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

AB - We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

KW - B-cell development

KW - Immunology

UR - https://www.scopus.com/pages/publications/84881103943

U2 - 10.1073/pnas.1218131110

DO - 10.1073/pnas.1218131110

M3 - Article

C2 - 23847204

AN - SCOPUS:84881103943

SN - 0027-8424

VL - 110

SP - E2915-E2924

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 31

ER -

Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

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Keywords

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