TY - JOUR
T1 - Extracellular matrix and its interactions in the diabetic kidney
T2 - A molecular biological approach
AU - Gilbert, Richard E.
AU - Cox, Alison
AU - Dziadek, Marie
AU - Cooper, Mark E.
AU - Jerums, George
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well understood, but is likely to involve interaction between cells, growth factors, structural proteins, and cell receptors for these molecules. Molecular biological techniques may offer the necessary tools for gaining insight into the pathogenetic processes that eventually lead to renal failure in diabetes.
AB - Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well understood, but is likely to involve interaction between cells, growth factors, structural proteins, and cell receptors for these molecules. Molecular biological techniques may offer the necessary tools for gaining insight into the pathogenetic processes that eventually lead to renal failure in diabetes.
UR - http://www.scopus.com/inward/record.url?scp=0028879102&partnerID=8YFLogxK
U2 - 10.1016/1056-8727(95)80015-7
DO - 10.1016/1056-8727(95)80015-7
M3 - Article
C2 - 8573740
AN - SCOPUS:0028879102
VL - 9
SP - 252
EP - 254
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 4
ER -
