Externally validated predictive clinical model for untreated del(17p13.1) chronic lymphocytic leukemia patients

Deborah M. Stephens, Amy S. Ruppert, William G. Weirda, Jeffrey A. Jones, Jennifer A. Woyach, Kami Maddocks, Samantha M. Jaglowski, Leslie A. Andritsos, Joseph M. Flynn, Michael R. Grever, Gerard Lozanski, Constantine Tam, Susan O'Brien, Michael J. Keating, Natarajan Muthusamy, Lynne V. Abruzzo, Nyla A. Heerema, John C. Byrd

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2 Citations (Scopus)

Abstract

Little is known about outcomes of patients with chronic lymphocytic leukemia (CLL) with del(17p13.1) karyotype at diagnosis. We reviewed 114 de novo del(17p13.1) CLL patients seen at our institution. Using proportional hazards models to identify pretreatment clinical variables significantly associated with treatment-free survival (TFS) and overall survival (OS), we developed a simplified risk score for de novo del(17p13.1) CLL patients to predict TFS and OS based on these variables. These scores, particularly the very highest, can be utilized to identify high-risk patients for expedient enrollment on clinical trials. Our data support careful observation for low-risk patients, potentially preventing unnecessary use of aggressive therapies.

Original languageEnglish
Pages (from-to)967-969
Number of pages3
JournalAmerican Journal of Hematology
Volume90
Issue number11
DOIs
Publication statusPublished - Nov 2015
Externally publishedYes

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