Abstract
Wnt proteins are often up-regulated in cancer. The secreted frizzled-related proteins (sFRPs) can abrogate Wnt signalling and are involved in apoptosis. We investigated the expression of Wnt1, β-Catenin, and an antagonist, sFRP4, as well as apoptosis in breast cancer using tissue micro-arrays (TMAs) comprising 191 tissue cores. Results demonstrated stronger staining intensity for Wnt1 in tumour versus non-tumour samples (p<0.05). Epithelial sFRP4 did not differ between invasive and non-invasive tissue; however, there was increased sFRP4 expression in the blood vessels and lymphocyte cells of tumour compared to non-tumour tissue. These data suggest Wnt involvement in determining the breast cancer phenotype and highlight a potential new role for sFRP4 as a diagnostic/prognostic marker.
Original language | English |
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Pages (from-to) | 205-212 |
Number of pages | 8 |
Journal | Journal of Analytical Oncology |
Volume | 3 |
DOIs | |
Publication status | Published - 29 Oct 2014 |
Externally published | Yes |
Keywords
- Breast
- Cancer
- Secreted frizzled-related protein 4
- Tissue micro-arrays
- Wnt