TY - JOUR
T1 - Expression Pattern of p62 in Primary Age-Related Tauopathy
T2 - Staging of p62 in PART
AU - Wang, Xin
AU - Zhang, Lei
AU - Lu, Hui
AU - Wu, Juanli
AU - Liang, Huazheng
AU - Sun, Bing
AU - Zhu, Keqing
N1 - Funding Information:
This research was supported by the National Science Foundation China (81971184) (to KZ), (91632109) (to Zhong and KZ), by the Zhejiang Provincial Natural Science Foundation (LY16H090013) (to KZ), and by the Zhejiang Medical and Health Science and Technology Plan Project (WKJ2013-2-009) (to KZ).
Publisher Copyright:
Copyright © 2022 Wang, Zhang, Lu, Wu, Liang, Sun and Zhu.
PY - 2022/4/25
Y1 - 2022/4/25
N2 - The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation. In PART and AD brains, p62 was found positive in seven regions, including the neocortex, thalamus, basal ganglia, hippocampus, brainstem, cerebellar dentate nucleus, and the cervical spinal cord. There was a positive correlation between the Braak NFT stage and the distribution of p62 expression. Six stages of expression of p62 were proposed from the present study. Expression of p62 in the hippocampus of PART and AD was classified stage I, the brainstem stage II, the thalamus stage I _I _I, the basal ganglia stage IV, the neocortex stage V, the cerebellum and the cervical spinal cord stage VI. The hippocampus was the site initially affected by p62, especially the CA1 and the subiculum. They might be the earliest accumulation site of p62.
AB - The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation. In PART and AD brains, p62 was found positive in seven regions, including the neocortex, thalamus, basal ganglia, hippocampus, brainstem, cerebellar dentate nucleus, and the cervical spinal cord. There was a positive correlation between the Braak NFT stage and the distribution of p62 expression. Six stages of expression of p62 were proposed from the present study. Expression of p62 in the hippocampus of PART and AD was classified stage I, the brainstem stage II, the thalamus stage I _I _I, the basal ganglia stage IV, the neocortex stage V, the cerebellum and the cervical spinal cord stage VI. The hippocampus was the site initially affected by p62, especially the CA1 and the subiculum. They might be the earliest accumulation site of p62.
KW - Alzheimier’s disease
KW - Braak NFT stage
KW - hippocampus
KW - p62
KW - primary age-related tauopathy
UR - http://www.scopus.com/inward/record.url?scp=85129987910&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.793353
DO - 10.3389/fnagi.2022.793353
M3 - Article
C2 - 35547629
AN - SCOPUS:85129987910
SN - 1663-4365
VL - 14
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 793353
ER -