Expression of JAK/STAT signalling in bullous pemphigoid

Laxmi Iyengar; Patrick Hosking; Joel Dowsett; John Su

doi:10.1111/ajd.14389

Expression of JAK/STAT signalling in bullous pemphigoid

Laxmi Iyengar, Patrick Hosking, Joel Dowsett, John Su

Eastern Health Clinical School Research

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.

Original language	English
Pages (from-to)	e10-e13
Number of pages	4
Journal	Australasian Journal of Dermatology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1111/ajd.14389
Publication status	Published - Feb 2025

Keywords

bullous pemphigoid
JAK signalling
phosphorylated STAT

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10.1111/ajd.14389

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title = "Expression of JAK/STAT signalling in bullous pemphigoid",

abstract = "In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.",

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author = "Laxmi Iyengar and Patrick Hosking and Joel Dowsett and John Su",

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AU - Iyengar, Laxmi

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AU - Dowsett, Joel

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AB - In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.

KW - bullous pemphigoid

KW - JAK signalling

KW - phosphorylated STAT

UR - https://www.scopus.com/pages/publications/85210035112

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JO - Australasian Journal of Dermatology

JF - Australasian Journal of Dermatology

IS - 1

ER -

Expression of JAK/STAT signalling in bullous pemphigoid

Abstract

Keywords

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