TY - JOUR
T1 - Expression of CD71 by flow cytometry in acute leukemias
T2 - More often seen in acute myeloid leukemia
AU - Pande, Amit
AU - Dorwal, Pranav
AU - Jain, Dharmendra
AU - Tyagi, Neetu
AU - Mehra, Simmi
AU - Sachdev, Ritesh
AU - Raina, Vimarsh
N1 - Publisher Copyright:
© 2016 Indian Journal of Pathology and Microbiology | Publishedby Wolters Kluwer - Medknow.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background: CD71 is a marker that has been usually used for identifying dysplasia in the erythroid series. We have tried to evaluate the expression of CD71 in various types of acute leukemias. Materials and Methods: We studied 48 patients of acute leukemia, of which 25 were acute myeloid leukemia (AML), 13 were precursor B-acute lymphoblastic leukemia (B-ALL), 8 were T-ALL, and 2 were mixed phenotype acute leukemia (T/myeloid) as per the WHO classification. Results: We found that the expression of CD71 was most prevalent in AMLs (84%), followed by T-ALL (50%) and least in B-ALL (30%). Conclusion: This finding clearly shows the higher expression of CD71 in AMLs compared to other common type of leukemias, such as B- and T-ALL. We suggest that the high expression of CD71 in AMLs could be used as a diagnostic marker and may also be used for minimal residual disease analysis after further studies in posttreatment scenario. This study is the first of its kind in the South Asian population.
AB - Background: CD71 is a marker that has been usually used for identifying dysplasia in the erythroid series. We have tried to evaluate the expression of CD71 in various types of acute leukemias. Materials and Methods: We studied 48 patients of acute leukemia, of which 25 were acute myeloid leukemia (AML), 13 were precursor B-acute lymphoblastic leukemia (B-ALL), 8 were T-ALL, and 2 were mixed phenotype acute leukemia (T/myeloid) as per the WHO classification. Results: We found that the expression of CD71 was most prevalent in AMLs (84%), followed by T-ALL (50%) and least in B-ALL (30%). Conclusion: This finding clearly shows the higher expression of CD71 in AMLs compared to other common type of leukemias, such as B- and T-ALL. We suggest that the high expression of CD71 in AMLs could be used as a diagnostic marker and may also be used for minimal residual disease analysis after further studies in posttreatment scenario. This study is the first of its kind in the South Asian population.
KW - Acute leukemia
KW - acute lymphoblastic leukemia
KW - acute myeloid leukemia
KW - CD71
KW - flow cytometry
UR - https://www.scopus.com/pages/publications/84982157014
U2 - 10.4103/0377-4929.188145
DO - 10.4103/0377-4929.188145
M3 - Article
C2 - 27510666
AN - SCOPUS:84982157014
SN - 0377-4929
VL - 59
SP - 310
EP - 313
JO - Indian Journal of Pathology and Microbiology
JF - Indian Journal of Pathology and Microbiology
IS - 3
ER -