Expression of CD45 isoforms in chronic B-cell leukaemias

Heddy Zola; Naomi Siderius; Loretta Flego; Rosemary Sparrow; Martin B. Van Der Weyden; Joy Nimmo; Derek N.J. Hart; Sue Houghton; Andrew W. Boyd

doi:10.1016/0145-2126(93)90003-4

Expression of CD45 isoforms in chronic B-cell leukaemias

Heddy Zola, Naomi Siderius, Loretta Flego, Rosemary Sparrow, Martin B. Van Der Weyden, Joy Nimmo, Derek N.J. Hart, Sue Houghton, Andrew W. Boyd

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL). In almost half the samples tested, CD45R0 was co-expressed with CD45RA, unlike normal B-cells, which express only CD45RA, except at terminal stages of differentiation. In a small number of cases CD45R0 was the dominant isoform expressed. No correlation could be discerned either with Binet or RAI staging in CLL or with disease type CLL, prolymphocytic leukaemia (PLL) or hairy cell leukaemia (HCL). Comparison of CD45 isoform expression with other markers showed no correlation with apparent maturational status of the cells involved.

Original language	English
Pages (from-to)	209-216
Number of pages	8
Journal	Leukemia Research
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0145-2126(93)90003-4
Publication status	Published - Mar 1993
Externally published	Yes

Keywords

B-cell leukaemia
CD45
CLL
leukocyte-common antigen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0145-2126(93)90003-4

Cite this

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title = "Expression of CD45 isoforms in chronic B-cell leukaemias",

abstract = "CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL). In almost half the samples tested, CD45R0 was co-expressed with CD45RA, unlike normal B-cells, which express only CD45RA, except at terminal stages of differentiation. In a small number of cases CD45R0 was the dominant isoform expressed. No correlation could be discerned either with Binet or RAI staging in CLL or with disease type CLL, prolymphocytic leukaemia (PLL) or hairy cell leukaemia (HCL). Comparison of CD45 isoform expression with other markers showed no correlation with apparent maturational status of the cells involved.",

keywords = "B-cell leukaemia, CD45, CLL, leukocyte-common antigen",

author = "Heddy Zola and Naomi Siderius and Loretta Flego and Rosemary Sparrow and {Van Der Weyden}, {Martin B.} and Joy Nimmo and Hart, {Derek N.J.} and Sue Houghton and Boyd, {Andrew W.}",

note = "Funding Information: Acknowledgements--These studies were supported by grants from the Anti-Cancer Foundation (South Australia). We are grateful to Drs Marion Roberts and David Gillis, and to Ms Joy Mundy, of the Institute of Medical and Veterinary Science, Adelaide, for patient samples, to Mr Joseph Webster for flow cytometry and to Mrs Mary Brown for secretarial assistance. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1993",

month = mar,

doi = "10.1016/0145-2126(93)90003-4",

language = "English",

volume = "17",

pages = "209--216",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Expression of CD45 isoforms in chronic B-cell leukaemias

AU - Zola, Heddy

AU - Siderius, Naomi

AU - Flego, Loretta

AU - Sparrow, Rosemary

AU - Van Der Weyden, Martin B.

AU - Nimmo, Joy

AU - Hart, Derek N.J.

AU - Houghton, Sue

AU - Boyd, Andrew W.

N1 - Funding Information: Acknowledgements--These studies were supported by grants from the Anti-Cancer Foundation (South Australia). We are grateful to Drs Marion Roberts and David Gillis, and to Ms Joy Mundy, of the Institute of Medical and Veterinary Science, Adelaide, for patient samples, to Mr Joseph Webster for flow cytometry and to Mrs Mary Brown for secretarial assistance. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1993/3

Y1 - 1993/3

N2 - CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL). In almost half the samples tested, CD45R0 was co-expressed with CD45RA, unlike normal B-cells, which express only CD45RA, except at terminal stages of differentiation. In a small number of cases CD45R0 was the dominant isoform expressed. No correlation could be discerned either with Binet or RAI staging in CLL or with disease type CLL, prolymphocytic leukaemia (PLL) or hairy cell leukaemia (HCL). Comparison of CD45 isoform expression with other markers showed no correlation with apparent maturational status of the cells involved.

AB - CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL). In almost half the samples tested, CD45R0 was co-expressed with CD45RA, unlike normal B-cells, which express only CD45RA, except at terminal stages of differentiation. In a small number of cases CD45R0 was the dominant isoform expressed. No correlation could be discerned either with Binet or RAI staging in CLL or with disease type CLL, prolymphocytic leukaemia (PLL) or hairy cell leukaemia (HCL). Comparison of CD45 isoform expression with other markers showed no correlation with apparent maturational status of the cells involved.

KW - B-cell leukaemia

KW - CD45

KW - CLL

KW - leukocyte-common antigen

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U2 - 10.1016/0145-2126(93)90003-4

DO - 10.1016/0145-2126(93)90003-4

M3 - Article

C2 - 7680734

AN - SCOPUS:0027418559

SN - 0145-2126

VL - 17

SP - 209

EP - 216

JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

Expression of CD45 isoforms in chronic B-cell leukaemias

Abstract

Keywords

UN SDGs

Access to Document

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