Expression of a novel family of epitopes on small intestinal mucins in colorectal cancers, adjacent and remote mucosa

S. J. Pilbrow, P. J. Hertzog, G. D. Pinczower, A. W. Linnane

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6 Citations (Scopus)

Abstract

We describe the production, immunochemical and immuno-histochemical characterization of monoclonal antibodies (MAbs) raised against the oncofetal small intestinal mucin antigen (SIMA). Four MAbs. reacting with distinct neuramini-dase-sensitivc SIMA epitopes, were shown to define a novel differentiation-associated relationship of SIMA epitopes within the normal small intestinal villus. Using Swiss rolls of 15 entire colorectal cancer resections, inappropriate expression of SIMA epitopes was detected in all cancers, in adjacent transitional mucosa and remote morphologically normal mucosa. extending as far as resection margins (73%). SIMA expression, whether preexisting or reactive to the tumor, may predispose to malignant change and tumor recurrence.

Original languageEnglish
Pages (from-to)251-267
Number of pages17
JournalTumor Biology
Volume13
Issue number5-6
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • Colorectal cancer
  • Immunochemistry
  • Immunohistochemislry
  • Monoclonal antibody
  • Mucin
  • Oncofetal
  • Transitional mucosa

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