Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Larissa J Prior; Pamela J Davern; Sandra L Burke; Kyung Lim; James A Armitage; Geoffrey A Head

doi:10.1161/HYPERTENSIONAHA.113.02498

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Larissa J Prior, Pamela J Davern, Sandra L Burke, Kyung Lim, James A Armitage, Geoffrey A Head

Pharmacology

Research output: Contribution to journal › Article › Research › peer-review

60 Citations (Scopus)

Abstract

Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P

Original language	English
Pages (from-to)	338 - 345
Number of pages	8
Journal	Hypertension
Volume	63
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02498
Publication status	Published - 2014

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10.1161/HYPERTENSIONAHA.113.02498

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AU - Prior, Larissa J

AU - Davern, Pamela J

AU - Burke, Sandra L

AU - Lim, Kyung

AU - Armitage, James A

AU - Head, Geoffrey A

PY - 2014

Y1 - 2014

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DO - 10.1161/HYPERTENSIONAHA.113.02498

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JO - Hypertension

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Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Abstract

UN SDGs

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Understanding the contribution of sympathetic overactivity to maternally programmed obesity related hypertension

Cite this

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Abstract

UN SDGs

Access to Document

Other files and links

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Understanding the contribution of sympathetic overactivity to maternally programmed obesity related hypertension

Cite this