Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Larissa J Prior, Pamela J Davern, Sandra L Burke, Kyung Lim, James A Armitage, Geoffrey A Head

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P
Original languageEnglish
Pages (from-to)338 - 345
Number of pages8
JournalHypertension
Volume63
Issue number2
DOIs
Publication statusPublished - 2014

Cite this

@article{2e36aef9dec04bb08299fd726149a0fa,
title = "Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits",
abstract = "Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P",
author = "Prior, {Larissa J} and Davern, {Pamela J} and Burke, {Sandra L} and Kyung Lim and Armitage, {James A} and Head, {Geoffrey A}",
year = "2014",
doi = "10.1161/HYPERTENSIONAHA.113.02498",
language = "English",
volume = "63",
pages = "338 -- 345",
journal = "Hypertension",
issn = "0194-911X",
publisher = "American Heart Association",
number = "2",

}

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. / Prior, Larissa J; Davern, Pamela J; Burke, Sandra L; Lim, Kyung; Armitage, James A; Head, Geoffrey A.

In: Hypertension, Vol. 63, No. 2, 2014, p. 338 - 345.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

AU - Prior, Larissa J

AU - Davern, Pamela J

AU - Burke, Sandra L

AU - Lim, Kyung

AU - Armitage, James A

AU - Head, Geoffrey A

PY - 2014

Y1 - 2014

N2 - Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P

AB - Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P

UR - http://hyper.ahajournals.org/content/63/2/338.full.pdf+html

U2 - 10.1161/HYPERTENSIONAHA.113.02498

DO - 10.1161/HYPERTENSIONAHA.113.02498

M3 - Article

VL - 63

SP - 338

EP - 345

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2

ER -