Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Larissa J Prior, Pamela J Davern, Sandra L Burke, Kyung Lim, James A Armitage, Geoffrey A Head

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Abstract

Exposure to maternal obesity or a maternal diet rich in fat during development may have adverse outcomes in offspring, such as the development of obesity and hypertension. The present study examined the effect of a maternal high-fat diet (m-HFD) on offspring blood pressure and renal sympathetic nerve activity, responses to stress, and sensitivity to central administration of leptin and ghrelin. Offspring of New Zealand white rabbits fed a 13 HFD were slightly heavier than offspring from mothers fed a 4 maternal normal fat diet (P
Original languageEnglish
Pages (from-to)338 - 345
Number of pages8
JournalHypertension
Volume63
Issue number2
DOIs
Publication statusPublished - 2014

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