Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

Katherine H. Franks; Lachlan Cribb; Lisa Bransby; Rachel Buckley; Nawaf Yassi; Trevor T.J. Chong; Yen Ying Lim; Matthew P. Pase

doi:10.3233/ADR-230052

Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

Katherine H. Franks, Lachlan Cribb, Lisa Bransby, Rachel Buckley, Nawaf Yassi, Trevor T.J. Chong, Yen Ying Lim, Matthew P. Pase

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f² effect sizes were small in magnitude (f²≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

Original language	English
Pages (from-to)	1025-1031
Number of pages	7
Journal	Journal of Alzheimer's Disease Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.3233/ADR-230052
Publication status	Published - 19 Sept 2023

Keywords

Alzheimer's disease
amyloid
biomarkers
dementia
psychological stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/ADR-230052Licence: CC BY-NC

Cite this

Franks, K. H., Cribb, L., Bransby, L., Buckley, R., Yassi, N., Chong, T. T. J., Lim, Y. Y., & Pase, M. P. (2023). Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study. Journal of Alzheimer's Disease Reports, 7(1), 1025-1031. https://doi.org/10.3233/ADR-230052

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title = "Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study",

abstract = "Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.",

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note = "Funding Information: LB is supported by a Dementia Australia Research Foundation PhD scholarship. RB is supported by a National Institutes of Health K99-R00 award (K99AG061238) and an Alzheimer{\textquoteright}s Association Research Fellowship (AARF-20-675646). TC is supported by the Australian Research Council (FT220100294). YYL is supported by a National Health and Medical Research Council of Australia Career Development Fellowship (GNT1162645) and a National Health and Medical Research Council of Australia Emerging Leadership 2 Investigator Grant (GNT2009550). MP is supported by a National Health and Medical Research Council of Australia Emerging Leadership 2 Investigator Grant (GTN2009264). Publisher Copyright: {\textcopyright} 2023 - The authors. Published by IOS Press.",

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Franks, KH, Cribb, L, Bransby, L, Buckley, R, Yassi, N, Chong, TTJ , Lim, YY & Pase, MP 2023, 'Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study', Journal of Alzheimer's Disease Reports, vol. 7, no. 1, pp. 1025-1031. https://doi.org/10.3233/ADR-230052

Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study. / Franks, Katherine H.; Cribb, Lachlan; Bransby, Lisa et al.
In: Journal of Alzheimer's Disease Reports, Vol. 7, No. 1, 19.09.2023, p. 1025-1031.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Yassi, Nawaf

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AU - Lim, Yen Ying

AU - Pase, Matthew P.

N1 - Funding Information: LB is supported by a Dementia Australia Research Foundation PhD scholarship. RB is supported by a National Institutes of Health K99-R00 award (K99AG061238) and an Alzheimer’s Association Research Fellowship (AARF-20-675646). TC is supported by the Australian Research Council (FT220100294). YYL is supported by a National Health and Medical Research Council of Australia Career Development Fellowship (GNT1162645) and a National Health and Medical Research Council of Australia Emerging Leadership 2 Investigator Grant (GNT2009550). MP is supported by a National Health and Medical Research Council of Australia Emerging Leadership 2 Investigator Grant (GTN2009264). Publisher Copyright: © 2023 - The authors. Published by IOS Press.

PY - 2023/9/19

Y1 - 2023/9/19

N2 - Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

AB - Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

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AN - SCOPUS:85173238390

SN - 2542-4823

VL - 7

SP - 1025

EP - 1031

JO - Journal of Alzheimer's Disease Reports

JF - Journal of Alzheimer's Disease Reports

IS - 1

ER -

Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

The neurobiology of curiosity

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Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

The neurobiology of curiosity

Unravelling the Contributions of Sleep Dysfunction to Alzheimer’s Disease and Dementia

Risk and resilience in Alzheimer's pathogenesis, cognitive decline and clinical disease progression

Cite this