Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Midlife: A Cross-Sectional Study

Katherine H. Franks, Lachlan Cribb, Lisa Bransby, Rachel Buckley, Nawaf Yassi, Trevor T.J. Chong, Yen Ying Lim, Matthew P. Pase

Research output: Contribution to journalArticleResearchpeer-review


Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen's f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.

Original languageEnglish
Pages (from-to)1025-1031
Number of pages7
JournalJournal of Alzheimer's Disease Reports
Issue number1
Publication statusPublished - 19 Sept 2023


  • Alzheimer's disease
  • amyloid
  • biomarkers
  • dementia
  • psychological stress

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