Exploring perinatal biopsychosocial factors and epigenetic age in 1-year-old offspring

Peter D. Fransquet; Jacqui A. MacDonald; Joanne Ryan; Christopher J. Greenwood; Craig A. Olsson

doi:10.2217/epi-2023-0284

Exploring perinatal biopsychosocial factors and epigenetic age in 1-year-old offspring

Peter D. Fransquet, Jacqui A. MacDonald, Joanne Ryan, Christopher J. Greenwood, Craig A. Olsson

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Background: Little is known about the determinants of epigenetic aging in pediatric populations. Methods: Epigenetic age was estimated from 258 1-year-olds, using pediatric buccal epigenetic and Horvath clocks. We explored associations between epigenetic age and maternal indicators of mental and relational health, substance use and general physical health assessed during trimester three. Results: Higher anxiety and stress, BMI and higher parent-parent relationship quality were associated with pediatric buccal epigenetic clock differences. High blood pressure during pregnancy was associated with Horvath age acceleration. Third-trimester smoking and pre-pregnancy weight were associated with acceleration and deceleration respectively, and concordant across clocks. Conclusion: A broad range of maternal factors may shape epigenetic age in infancy; further research is needed to explore the possible effects on health and development.

Original language	English
Pages (from-to)	927-939
Number of pages	13
Journal	Epigenomics
Volume	15
Issue number	18
DOIs	https://doi.org/10.2217/epi-2023-0284
Publication status	Published - 1 Sept 2023

Keywords

aging
DNA methylation
epigenetic clock
Horvath
mental health
PedBE
pediatrics
perinatal
substance use

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/epi-2023-0284

Cite this

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title = "Exploring perinatal biopsychosocial factors and epigenetic age in 1-year-old offspring",

abstract = "Background: Little is known about the determinants of epigenetic aging in pediatric populations. Methods: Epigenetic age was estimated from 258 1-year-olds, using pediatric buccal epigenetic and Horvath clocks. We explored associations between epigenetic age and maternal indicators of mental and relational health, substance use and general physical health assessed during trimester three. Results: Higher anxiety and stress, BMI and higher parent-parent relationship quality were associated with pediatric buccal epigenetic clock differences. High blood pressure during pregnancy was associated with Horvath age acceleration. Third-trimester smoking and pre-pregnancy weight were associated with acceleration and deceleration respectively, and concordant across clocks. Conclusion: A broad range of maternal factors may shape epigenetic age in infancy; further research is needed to explore the possible effects on health and development.",

keywords = "aging, DNA methylation, epigenetic clock, Horvath, mental health, PedBE, pediatrics, perinatal, substance use",

author = "Fransquet, {Peter D.} and MacDonald, {Jacqui A.} and Joanne Ryan and Greenwood, {Christopher J.} and Olsson, {Craig A.}",

note = "Funding Information: Funding for this work was supported by grants from the Australian Research Council (DP130101459; DP160103160; DP180102447), the National Health and Medical Research Council of Australia (APP1082406; APP1175086) and Financial Markets Foundation for Children. Data collection for the ATP study was supported primarily through Australian grants from the Melbourne Royal Children{\textquoteright}s Hospital Research Foundation, National Health and Medical Research Council, Australian Research Council and the Australian Institute of Family Studies. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Competing interests disclosure Publisher Copyright: {\textcopyright} 2023 Peter D. Fransquet, Jacqui A. Macdonald, Joanne Ryan, Christopher J. Greenwood, Craig A. Olsson.",

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AU - MacDonald, Jacqui A.

AU - Ryan, Joanne

AU - Greenwood, Christopher J.

AU - Olsson, Craig A.

N1 - Funding Information: Funding for this work was supported by grants from the Australian Research Council (DP130101459; DP160103160; DP180102447), the National Health and Medical Research Council of Australia (APP1082406; APP1175086) and Financial Markets Foundation for Children. Data collection for the ATP study was supported primarily through Australian grants from the Melbourne Royal Children’s Hospital Research Foundation, National Health and Medical Research Council, Australian Research Council and the Australian Institute of Family Studies. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Competing interests disclosure Publisher Copyright: © 2023 Peter D. Fransquet, Jacqui A. Macdonald, Joanne Ryan, Christopher J. Greenwood, Craig A. Olsson.

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Background: Little is known about the determinants of epigenetic aging in pediatric populations. Methods: Epigenetic age was estimated from 258 1-year-olds, using pediatric buccal epigenetic and Horvath clocks. We explored associations between epigenetic age and maternal indicators of mental and relational health, substance use and general physical health assessed during trimester three. Results: Higher anxiety and stress, BMI and higher parent-parent relationship quality were associated with pediatric buccal epigenetic clock differences. High blood pressure during pregnancy was associated with Horvath age acceleration. Third-trimester smoking and pre-pregnancy weight were associated with acceleration and deceleration respectively, and concordant across clocks. Conclusion: A broad range of maternal factors may shape epigenetic age in infancy; further research is needed to explore the possible effects on health and development.

AB - Background: Little is known about the determinants of epigenetic aging in pediatric populations. Methods: Epigenetic age was estimated from 258 1-year-olds, using pediatric buccal epigenetic and Horvath clocks. We explored associations between epigenetic age and maternal indicators of mental and relational health, substance use and general physical health assessed during trimester three. Results: Higher anxiety and stress, BMI and higher parent-parent relationship quality were associated with pediatric buccal epigenetic clock differences. High blood pressure during pregnancy was associated with Horvath age acceleration. Third-trimester smoking and pre-pregnancy weight were associated with acceleration and deceleration respectively, and concordant across clocks. Conclusion: A broad range of maternal factors may shape epigenetic age in infancy; further research is needed to explore the possible effects on health and development.

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Exploring perinatal biopsychosocial factors and epigenetic age in 1-year-old offspring

Abstract

Keywords

UN SDGs

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Other files and links

Preconception determinants of child health and development: A 4-year follow up of offspring born to the Australian Temperament Project

Cite this

Exploring perinatal biopsychosocial factors and epigenetic age in 1-year-old offspring

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Preconception determinants of child health and development: A 4-year follow up of offspring born to the Australian Temperament Project

Cite this