Exploration of Ultrasound-Sensitive Biomaterials in Cancer Theranostics

Yuqi Yang, Huazheng Liang, Chun Tang, Yuan Cheng, Liang Cheng

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)


Cancer is a serious health problem to be solved. With the development of biomaterials, enhanced diagnostic and controllable therapeutic strategies for cancer have emerged, revealing encouraging results with a promising future. Due to its outstanding tissue penetration and controllability, along with a series of bioeffects on tissues, ultrasound (US), as a common medical technology, has been regarded as an effective tool against cancer, and its use has promoted the exploration of US-sensitive biomaterials. In this review, the bioeffects of US are first introduced and then the main US-sensitive biomaterials (containing cavitation nuclei, sonosensitizers, and US-responsive macromolecular systems) used to treat cancer, followed by a summary of several applications based on US-sensitive biomaterials, from diagnosis to therapy. Finally, the emerging challenges in this field that need to be overcome are highlighted. This review reports the progress of US-sensitive biomaterials, providing new possibilities in cancer theranostics and thus benefiting patients.

Original languageEnglish
Number of pages20
JournalAdvanced Functional Materials
Publication statusAccepted/In press - 6 Jan 2024


  • biomaterials
  • cancer therapy
  • drug delivery
  • sonodynamic therapy
  • ultrasound

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