Expired CO2 levels indicate degree of lung aeration at birth

Stuart Brian Hooper, Andreas Fouras, Melissa Li-Lian Siew, Megan Jane Wallace, Marcus John Kitchen, Arjan B Te Pas, Claus Klingenberg, Robert Lewis, Peter G Davis, Colin J Morley, Georg Marcus Schmolzer

Research output: Contribution to journalArticleResearchpeer-review

Abstract

As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels were significantly (p10 mmHg 28 (median) (21-36) seconds before the heart rate increased above 100 beats per minute. These data demonstrate that ECO2 levels can indicate the relative degree of lung aeration after birth and can be used to clinically assess ventilation in the immediate newborn period.
Original languageEnglish
Article numbere70895
Number of pages11
JournalPLoS ONE
Volume8
Issue number8
DOIs
Publication statusPublished - 2013

Cite this

Hooper, Stuart Brian ; Fouras, Andreas ; Siew, Melissa Li-Lian ; Wallace, Megan Jane ; Kitchen, Marcus John ; Te Pas, Arjan B ; Klingenberg, Claus ; Lewis, Robert ; Davis, Peter G ; Morley, Colin J ; Schmolzer, Georg Marcus. / Expired CO2 levels indicate degree of lung aeration at birth. In: PLoS ONE. 2013 ; Vol. 8, No. 8.
@article{65566dd626da40298591cbc51eacca43,
title = "Expired CO2 levels indicate degree of lung aeration at birth",
abstract = "As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels were significantly (p10 mmHg 28 (median) (21-36) seconds before the heart rate increased above 100 beats per minute. These data demonstrate that ECO2 levels can indicate the relative degree of lung aeration after birth and can be used to clinically assess ventilation in the immediate newborn period.",
author = "Hooper, {Stuart Brian} and Andreas Fouras and Siew, {Melissa Li-Lian} and Wallace, {Megan Jane} and Kitchen, {Marcus John} and {Te Pas}, {Arjan B} and Claus Klingenberg and Robert Lewis and Davis, {Peter G} and Morley, {Colin J} and Schmolzer, {Georg Marcus}",
year = "2013",
doi = "10.1371/journal.pone.0070895",
language = "English",
volume = "8",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

Hooper, SB, Fouras, A, Siew, ML-L, Wallace, MJ, Kitchen, MJ, Te Pas, AB, Klingenberg, C, Lewis, R, Davis, PG, Morley, CJ & Schmolzer, GM 2013, 'Expired CO2 levels indicate degree of lung aeration at birth' PLoS ONE, vol. 8, no. 8, e70895. https://doi.org/10.1371/journal.pone.0070895

Expired CO2 levels indicate degree of lung aeration at birth. / Hooper, Stuart Brian; Fouras, Andreas; Siew, Melissa Li-Lian; Wallace, Megan Jane; Kitchen, Marcus John; Te Pas, Arjan B; Klingenberg, Claus; Lewis, Robert; Davis, Peter G; Morley, Colin J; Schmolzer, Georg Marcus.

In: PLoS ONE, Vol. 8, No. 8, e70895, 2013.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Expired CO2 levels indicate degree of lung aeration at birth

AU - Hooper, Stuart Brian

AU - Fouras, Andreas

AU - Siew, Melissa Li-Lian

AU - Wallace, Megan Jane

AU - Kitchen, Marcus John

AU - Te Pas, Arjan B

AU - Klingenberg, Claus

AU - Lewis, Robert

AU - Davis, Peter G

AU - Morley, Colin J

AU - Schmolzer, Georg Marcus

PY - 2013

Y1 - 2013

N2 - As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels were significantly (p10 mmHg 28 (median) (21-36) seconds before the heart rate increased above 100 beats per minute. These data demonstrate that ECO2 levels can indicate the relative degree of lung aeration after birth and can be used to clinically assess ventilation in the immediate newborn period.

AB - As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels were significantly (p10 mmHg 28 (median) (21-36) seconds before the heart rate increased above 100 beats per minute. These data demonstrate that ECO2 levels can indicate the relative degree of lung aeration after birth and can be used to clinically assess ventilation in the immediate newborn period.

UR - http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0070895&representation=PDF

U2 - 10.1371/journal.pone.0070895

DO - 10.1371/journal.pone.0070895

M3 - Article

VL - 8

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

M1 - e70895

ER -