Experimental traumatic brain injury results in long-term recovery of functional responsiveness in sensory cortex but persisting structural changes and sensorimotor, cognitive, and emotional deficits

Victoria Phillipa Anne Johnstone, David K Wright, Kendrew K C Wong, Terence J O'Brien, Ramesh Rajan, Sandy R Shultz

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies we have shown that experimental TBI caused an immediate (24 hr post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex, and how these changes may contribute to a range of TBI morbidities. Adult male Sprague Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks recovery before behavioural assessment, magnetic resonance imaging (MRI), and electrophysiological recordings from the barrel cortex. The TBI rats demonstrated sensorimotor deficits, cognitive impairments, and anxiety-like behaviour, and this was associated with significant atrophy of the barrel cortex and other brain structures. Extracellular recordings from ipsilateral barrel cortex revealed normal neuronal responsiveness and diffusion tensor MRI showed increased fractional anisotropy, axial diffusivity, and tract density within this region. These findings suggest that the long-term recovery of neuronal responsiveness is due to structural reorganisation within this region. Therefore it is likely that long-term structural and functional changes within sensory cortex post-TBI may allow for recovery of neuronal responsiveness, but that this recovery does not remediate all behavioural deficits.
Original languageEnglish
Pages (from-to)1333 - 1346
Number of pages14
JournalJournal of Neurotrauma
Volume32
Issue number17
DOIs
Publication statusPublished - 2015

Cite this

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title = "Experimental traumatic brain injury results in long-term recovery of functional responsiveness in sensory cortex but persisting structural changes and sensorimotor, cognitive, and emotional deficits",
abstract = "Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies we have shown that experimental TBI caused an immediate (24 hr post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex, and how these changes may contribute to a range of TBI morbidities. Adult male Sprague Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks recovery before behavioural assessment, magnetic resonance imaging (MRI), and electrophysiological recordings from the barrel cortex. The TBI rats demonstrated sensorimotor deficits, cognitive impairments, and anxiety-like behaviour, and this was associated with significant atrophy of the barrel cortex and other brain structures. Extracellular recordings from ipsilateral barrel cortex revealed normal neuronal responsiveness and diffusion tensor MRI showed increased fractional anisotropy, axial diffusivity, and tract density within this region. These findings suggest that the long-term recovery of neuronal responsiveness is due to structural reorganisation within this region. Therefore it is likely that long-term structural and functional changes within sensory cortex post-TBI may allow for recovery of neuronal responsiveness, but that this recovery does not remediate all behavioural deficits.",
author = "Johnstone, {Victoria Phillipa Anne} and Wright, {David K} and Wong, {Kendrew K C} and O'Brien, {Terence J} and Ramesh Rajan and Shultz, {Sandy R}",
year = "2015",
doi = "10.1089/neu.2014.3785",
language = "English",
volume = "32",
pages = "1333 -- 1346",
journal = "Journal of Neurotrauma",
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AU - Johnstone, Victoria Phillipa Anne

AU - Wright, David K

AU - Wong, Kendrew K C

AU - O'Brien, Terence J

AU - Rajan, Ramesh

AU - Shultz, Sandy R

PY - 2015

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N2 - Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies we have shown that experimental TBI caused an immediate (24 hr post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex, and how these changes may contribute to a range of TBI morbidities. Adult male Sprague Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks recovery before behavioural assessment, magnetic resonance imaging (MRI), and electrophysiological recordings from the barrel cortex. The TBI rats demonstrated sensorimotor deficits, cognitive impairments, and anxiety-like behaviour, and this was associated with significant atrophy of the barrel cortex and other brain structures. Extracellular recordings from ipsilateral barrel cortex revealed normal neuronal responsiveness and diffusion tensor MRI showed increased fractional anisotropy, axial diffusivity, and tract density within this region. These findings suggest that the long-term recovery of neuronal responsiveness is due to structural reorganisation within this region. Therefore it is likely that long-term structural and functional changes within sensory cortex post-TBI may allow for recovery of neuronal responsiveness, but that this recovery does not remediate all behavioural deficits.

AB - Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies we have shown that experimental TBI caused an immediate (24 hr post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex, and how these changes may contribute to a range of TBI morbidities. Adult male Sprague Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks recovery before behavioural assessment, magnetic resonance imaging (MRI), and electrophysiological recordings from the barrel cortex. The TBI rats demonstrated sensorimotor deficits, cognitive impairments, and anxiety-like behaviour, and this was associated with significant atrophy of the barrel cortex and other brain structures. Extracellular recordings from ipsilateral barrel cortex revealed normal neuronal responsiveness and diffusion tensor MRI showed increased fractional anisotropy, axial diffusivity, and tract density within this region. These findings suggest that the long-term recovery of neuronal responsiveness is due to structural reorganisation within this region. Therefore it is likely that long-term structural and functional changes within sensory cortex post-TBI may allow for recovery of neuronal responsiveness, but that this recovery does not remediate all behavioural deficits.

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