Experimental traumatic brain injury does not lead to lung infection

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Abstract

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate whether TBI could lead to spontaneous lung infection. Analysis of bacterial load in lung tissue indicated no occurrence of spontaneous lung infection at 24 h, 48 h, and 7 d following LFPI. This may suggest that exogenous infectious agents play a crucial role in post-TBI infection in patients.

Original languageEnglish
Article number577239
Number of pages4
JournalJournal of Neuroimmunology
Volume343
DOIs
Publication statusPublished - 15 Jun 2020

Keywords

  • Lower respiratory tract infection
  • Pneumonia
  • Pulmonary infection
  • Spleen
  • TBI

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