Experimental proof of concept of nanoparticle-assisted STED

Yannick Sonnefraud, Hugo G. Sinclair, Yonatan Sivan, Matthew R. Foreman, Christopher W. Dunsby, Mark A.A. Neil, Paul M. French, Stefan A. Maier

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We imaged core-shell nanoparticles, consisting of a dye-doped silica core covered with a layer of gold, with a stimulated emission depletion, fluorescence lifetime imaging (STED-FLIM) microscope. Because of the field enhancement provided by the localized surface plasmon resonance of the gold shell, we demonstrate a reduction of the STED depletion power required to obtain resolution improvement by a factor of 4. This validates the concept of nanoparticle-assisted STED (NP-STED), where hybrid dye-plasmonic nanoparticles are used as labels for STED in order to decrease the depletion powers required for subwavelength imaging.

Original languageEnglish
Pages (from-to)4449-4453
Number of pages5
JournalNano Letters
Issue number8
Publication statusPublished - 13 Aug 2014
Externally publishedYes


  • fluorescence
  • microscopy
  • nanoshells
  • Plasmonics
  • STED microscopy

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