Experimental methods for flow and aerosol measurements in human airways and their replicas

Frantisek Lizal, Jan Jedelsky, Kaye Morgan, Katrin Bauer, Jordi Llop, Unai Cossio, Stavros Kassinos, Sylvia Verbanck, Jesús Ruiz-Cabello, Arnoldo Santos, Edmund Koch, Christian Schnabel

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.

Original languageEnglish
Pages (from-to)95-131
Number of pages37
JournalEuropean Journal of Pharmaceutical Sciences
Volume113
DOIs
Publication statusPublished - 15 Feb 2018
Externally publishedYes

Keywords

  • Aerosol deposition
  • CFD validation
  • Computational fluid particle dynamics
  • Experimental methods
  • Flow measurement techniques
  • Gas–liquid two-phase flow
  • Human airways
  • Lungs
  • Medical imaging
  • Velocimetry techniques

Cite this