Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model

Ruizhu Lin, Shihua Wang, Robert Chunhua Zhao

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)

Abstract

Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we show that MSCs secreted 40-100 nm particles, which have the typical characteristics of exosomes, and these MSC-derived exosomes promoted migration of the breast cancer cell line MCF7. Global gene expression profiling revealed that several cancer-related signaling pathways were upregulated after exosome treatment in MCF7, and the Wnt signaling pathway was further confirmed to be activated. Our findings demonstrated a new mechanism through which MSC-CM may contribute to tumor cell migration.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume383
Issue number1-2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Exosome
  • MCF7
  • Mesenchymal stem cell
  • Migration
  • Wnt

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