Exosome-mediated PROTACs delivery to target viral infections

Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh, Vetriselvan Subramaniyan, Rohit Sharma

Research output: Contribution to journalComment / DebateOtherpeer-review

12 Citations (Scopus)

Abstract

Exosome-based targeted delivery of Proteolysis-Targeting Chimeras (PROTACs) is an innovative approach that provides a promising solution for addressing the complex issues of viral diseases. This strategy significantly mitigates the off-target effects associated with traditional therapeutics by facilitating targeted delivery of PROTACs, which in turn enhances the overall therapeutic outcomes. Challenges like poor pharmacokinetics and unintended side effects, commonly observed with conventional PROTACs usage, are effectively managed with this approach. Emerging evidence affirms the potential of this delivery mechanism in curbing viral replication. However, it is crucial to undertake more comprehensive investigations for optimizing exosome-based delivery systems and conducting stringent safety and efficacy assessments within preclinical and clinical settings. The advancements in this field could potentially redefine the therapeutic landscape for viral diseases, opening new vistas for their management and treatment.

Original languageEnglish
Pages (from-to)1031-1036
Number of pages6
JournalDrug Development Research
Volume84
Issue number6
DOIs
Publication statusPublished - Sept 2023

Keywords

  • exosome
  • extracellular vesicles
  • infection
  • PROTACs
  • targeted delivery
  • viral diseases

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