TY - JOUR
T1 - ExoCarta
T2 - A Web-Based Compendium of Exosomal Cargo
AU - Keerthikumar, Shivakumar
AU - Chisanga, David
AU - Ariyaratne, Dinuka
AU - Al Saffar, Haidar
AU - Anand, Sushma
AU - Zhao, Kening
AU - Samuel, Monisha
AU - Pathan, Mohashin
AU - Jois, Markandeya
AU - Chilamkurti, Naveen
AU - Gangoda, Lahiru
AU - Mathivanan, Suresh
PY - 2016/2/22
Y1 - 2016/2/22
N2 - Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated Web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (> 54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, > 7540 RNA and 1116 lipid molecules from more than 286 exosomal studies annotated with International Society for Extracellular Vesicles minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich (http://www.funrich.org) tool for additional functional enrichment and interaction network analysis.
AB - Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated Web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (> 54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, > 7540 RNA and 1116 lipid molecules from more than 286 exosomal studies annotated with International Society for Extracellular Vesicles minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich (http://www.funrich.org) tool for additional functional enrichment and interaction network analysis.
UR - http://www.scopus.com/inward/record.url?scp=84959288708&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2015.09.019
DO - 10.1016/j.jmb.2015.09.019
M3 - Article
C2 - 26434508
AN - SCOPUS:84959288708
SN - 0022-2836
VL - 428
SP - 688
EP - 692
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 4
ER -