Exercise training improves long-term memory in obese mice

Oliver K. Fuller; Casey L. Egan; Tina L. Robinson; Nimna Perera; Heidy K. Latchman; Lauren V. Terry; Emma D. McLennan; Carolina Chavez; Emma L. Burrows; John W. Scott; Robyn M. Murphy; Henriette van Praag; Martin Whitham; Mark A. Febbraio

doi:10.1093/lifemeta/load043

Exercise training improves long-term memory in obese mice

Oliver K. Fuller, Casey L. Egan, Tina L. Robinson, Nimna Perera, Heidy K. Latchman, Lauren V. Terry, Emma D. McLennan, Carolina Chavez, Emma L. Burrows, John W. Scott, Robyn M. Murphy, Henriette van Praag, Martin Whitham, Mark A. Febbraio

Drug Discovery Biology

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2 Citations (Scopus)

Abstract

Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory and spatial cognition, reduce age-related cognitive decline, and preserve brain volume, but the mechanisms are not fully understood. Accordingly, we investigated whether any detrimental effects of high-fat diet (HFD)-induced obesity on cognition, motor behavior, adult hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) could be mitigated by voluntary exercise training in male C57Bl/6 mice. HFD-induced impairment of motor function was not reversed by exercise. Importantly, voluntary wheel running improved long-term memory and increased hippocampal neurogenesis, suggesting that regular physical activity may prevent cognitive decline in obesity.

Original language	English
Article number	load043
Number of pages	14
Journal	Life Metabolism
Volume	3
Issue number	1
DOIs	https://doi.org/10.1093/lifemeta/load043
Publication status	Published - 1 Feb 2024

Keywords

cognition
exercise
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/lifemeta/load043Licence: CC BY

Cite this

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title = "Exercise training improves long-term memory in obese mice",

abstract = "Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory and spatial cognition, reduce age-related cognitive decline, and preserve brain volume, but the mechanisms are not fully understood. Accordingly, we investigated whether any detrimental effects of high-fat diet (HFD)-induced obesity on cognition, motor behavior, adult hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) could be mitigated by voluntary exercise training in male C57Bl/6 mice. HFD-induced impairment of motor function was not reversed by exercise. Importantly, voluntary wheel running improved long-term memory and increased hippocampal neurogenesis, suggesting that regular physical activity may prevent cognitive decline in obesity.",

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author = "Fuller, {Oliver K.} and Egan, {Casey L.} and Robinson, {Tina L.} and Nimna Perera and Latchman, {Heidy K.} and Terry, {Lauren V.} and McLennan, {Emma D.} and Carolina Chavez and Burrows, {Emma L.} and Scott, {John W.} and Murphy, {Robyn M.} and {van Praag}, Henriette and Martin Whitham and Febbraio, {Mark A.}",

note = "Funding Information: M.A.F. is a Senior Principal Research Fellow of the NHMRC (APP1116936) and is also supported by an NHMRC Investigator Grant (APP1194141). Research in his laboratory was supported by project grants from the NHMRC (APP1042465, APP1041760, and APP1156511). Funding Information: The authors acknowledge the work of the staff at the animal research facilities at Monash Institute of Pharmaceutical Sciences, Monash University. The authors also acknowledge the contribution of Simon McKenzie-Nixon and Arthur Christopoulos for their contribution to this data set. We thank Linda Kitabayashi for her support and guidance in the histological analyses. M.A.F. is a Senior Principal Research Fellow of the NHMRC (APP1116936) and is also supported by an NHMRC Investigator Grant (APP1194141). Research in his laboratory was supported by project grants from the NHMRC (APP1042465, APP1041760, and APP1156511). Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.",

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doi = "10.1093/lifemeta/load043",

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AU - Fuller, Oliver K.

AU - Egan, Casey L.

AU - Robinson, Tina L.

AU - Perera, Nimna

AU - Latchman, Heidy K.

AU - Terry, Lauren V.

AU - McLennan, Emma D.

AU - Chavez, Carolina

AU - Burrows, Emma L.

AU - Scott, John W.

AU - Murphy, Robyn M.

AU - van Praag, Henriette

AU - Whitham, Martin

AU - Febbraio, Mark A.

N1 - Funding Information: M.A.F. is a Senior Principal Research Fellow of the NHMRC (APP1116936) and is also supported by an NHMRC Investigator Grant (APP1194141). Research in his laboratory was supported by project grants from the NHMRC (APP1042465, APP1041760, and APP1156511). Funding Information: The authors acknowledge the work of the staff at the animal research facilities at Monash Institute of Pharmaceutical Sciences, Monash University. The authors also acknowledge the contribution of Simon McKenzie-Nixon and Arthur Christopoulos for their contribution to this data set. We thank Linda Kitabayashi for her support and guidance in the histological analyses. M.A.F. is a Senior Principal Research Fellow of the NHMRC (APP1116936) and is also supported by an NHMRC Investigator Grant (APP1194141). Research in his laboratory was supported by project grants from the NHMRC (APP1042465, APP1041760, and APP1156511). Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

PY - 2024/2/1

Y1 - 2024/2/1

N2 - Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory and spatial cognition, reduce age-related cognitive decline, and preserve brain volume, but the mechanisms are not fully understood. Accordingly, we investigated whether any detrimental effects of high-fat diet (HFD)-induced obesity on cognition, motor behavior, adult hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) could be mitigated by voluntary exercise training in male C57Bl/6 mice. HFD-induced impairment of motor function was not reversed by exercise. Importantly, voluntary wheel running improved long-term memory and increased hippocampal neurogenesis, suggesting that regular physical activity may prevent cognitive decline in obesity.

AB - Obesity has been linked to a range of pathologies, including dementia. In contrast, regular physical activity is associated with the prevention or reduced progression of neurodegeneration. Specifically, physical activity can improve memory and spatial cognition, reduce age-related cognitive decline, and preserve brain volume, but the mechanisms are not fully understood. Accordingly, we investigated whether any detrimental effects of high-fat diet (HFD)-induced obesity on cognition, motor behavior, adult hippocampal neurogenesis, and brain-derived neurotrophic factor (BDNF) could be mitigated by voluntary exercise training in male C57Bl/6 mice. HFD-induced impairment of motor function was not reversed by exercise. Importantly, voluntary wheel running improved long-term memory and increased hippocampal neurogenesis, suggesting that regular physical activity may prevent cognitive decline in obesity.

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VL - 3

JO - Life Metabolism

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ER -

Exercise training improves long-term memory in obese mice

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Development of novel therapies to treat obesity related metabolic diseases

The designer cytokine IC7: a novel therapy for the treatment of type 2 Diabetes

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this

Exercise training improves long-term memory in obese mice

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Development of novel therapies to treat obesity related metabolic diseases

The designer cytokine IC7: a novel therapy for the treatment of type 2 Diabetes

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this