Excessive early-life dietary exposure: A potential source of elevated brain iron and a risk factor for Parkinson's disease

Dominic J. Hare, Bárbara Rita Cardoso, Erika P. Raven, Kay L. Double, David I. Finkelstein, Ewa A. Szymlek-Gay, Beverley Ann Biggs

Research output: Contribution to journalReview ArticleOtherpeer-review

17 Citations (Scopus)

Abstract

Iron accumulates gradually in the ageing brain. In Parkinson's disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson's diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson's disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson's disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson's diseases and produce a potential biomarker of Parkinson's disease risk in preclinical individuals.

Original languageEnglish
Article number0004
Number of pages5
Journalnpj Parkinson's Disease
Volume3
Issue number1
DOIs
Publication statusPublished - 5 Jan 2017
Externally publishedYes

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