Excess endogenous formaldehyde induces memory decline

Zhiqian Tong, Chanshuai Han, Junye Miao, Jing Lu, Rongqiao He

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


This review focuses on the relationship between excess endogenous formaldehyde and memory decline, multi-factors inducing formaldehyde abnormal accumulation and cognitive impairments. We discussed elevation of endogenous formaldehyde concentrations in Alzheimer's animal models and clinical patients. Injection with formaldehyde (referred to the detected level in the AD animal models) into normal mice obviously induced spatial memory decline. Aging, genetic factors diet and environmental pollutants led to formaldehyde abnormal accumulation. Formaldehyde scavengers could rescue spatial memory of APP-transgenic mice. These studies addressed that excess formaldehyde-induced damage of brain is one of the critical factors of cognitive impairments of sporadic senile dementia. Scavenging excess formaldehyde may be a novel therapy for Alzheimer's disease.

Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalProgress in Biochemistry and Biophysics
Issue number6
Publication statusPublished - 1 Jan 2011
Externally publishedYes


  • Endogenous formaldehyde
  • Formaldehyde stress
  • Memory decline
  • Senile dementia
  • Visual spatial memory

Cite this