@article{ccbb9d1b7dd549f0958ca09321c47ee6,
title = "Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours",
abstract = "Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders. ",
keywords = "Brain network, Compulsivity, Connectome, Impulsivity, Transdiagnostic",
author = "Yann Chye and Chao Suo and Rafael Romero-Garcia and Bethlehem, {Richard A.I.} and Roxanne Hook and Jeggan Tiego and Ian Goodyer and Jones, {Peter B.} and Ray Dolan and Bullmore, {Edward T.} and Grant, {Jon E.} and Murat Y{\"u}cel and Chamberlain, {Samuel R.}",
note = "Funding Information: Y.C. was supported by National Health and Medical Research Council (NHMRC) project grant 1139979. R.R.-G. was funded by a Guarantors of Brain fellowship. E.T.B. is an NIHR Senior Investigator. R.A.I.B. was funded by a British Academy postdoctoral fellowship. S.R.C. consults for Ieso Digital Health, and receives stipends from Elsevier for editorial work at Comprehensive Psychiatry and Neuroscience & Biobehavioral Reviews. J.E.G. has received research grants from the National Institute on Drug Abuse (NIDA), National Center for Responsible Gaming, American Foundation for Suicide Prevention, Forest Pharmaceuticals and Roche Pharmaceuticals; receives yearly compensation from Springer Publishing for acting as Editor-in-Chief of the Journal of Gambling Studies; and has received royalties from Oxford University Press, American Psychiatric Publishing, Norton Press, Johns Hopkins University Press and McGraw Hill. J.T. was supported by NHMRC project grants 1002458 and 1046054. I.G. consults for Lundbeck; is supported by a Wellcome Trust Strategic Award; and is Chairperson of and scientific advisor to the Peter Cundill Centre for Youth Depression Research, Centre for Addictions and Mental Health, University of Toronto. E.T.B. is a member of the Sosei Heptares scientific advisory board and is a National Institute of Health Research Senior Investigator. M.Y. has received funding from Monash University and Australian Government funding bodies such as the NHMRC (including fellowship APP1117188), the Australian Research Council, Australian Defense Science and Technology, and the Department of Industry, Innovation and Science. He has also received philanthropic donations from the David Winston Turner Endowment Fund and the Wilson Foundation; and payment from law firms in relation to court, expert witness and/or expert review reports. The funding sources had no role in the design, management, data analysis, presentation, interpretation or write-up of the data. The other authors report no disclosures or potential conflicts of interest. Funding Information: This research was funded by a clinical fellowship from the Wellcome Trust to S.R.C. (reference 110049/Z/15/Z &/A). The study was supported by the Neuroscience in Psychiatry Network, a strategic award from the Wellcome Trust to the University of Cambridge and University College London (reference 095844/Z/11/Z); and by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Mental Health). Publisher Copyright: Copyright {\textcopyright} The Author(s), 2021.",
year = "2022",
month = feb,
day = "14",
doi = "10.1192/bjp.2021.49",
language = "English",
volume = "220",
pages = "76--78",
journal = "The British Journal of Psychiatry",
issn = "0007-1250",
publisher = "Cambridge University Press",
number = "2",
}
