TY - JOUR
T1 - Examining post-concussion white matter change in a pediatric sample
AU - Takagi, Michael
AU - Ball, Gareth
AU - Babl, Franz E.
AU - Anderson, Nicholas
AU - Chen, Jian
AU - Clarke, Cathriona
AU - Davis, Gavin A.
AU - Hearps, Stephen J.C.
AU - Pascouau, Renee
AU - Cheng, Nicholas
AU - Rausa, Vanessa C.
AU - Seal, Marc
AU - Shapiro, Jesse S.
AU - Anderson, Vicki
N1 - Funding Information:
The study is funded by a project grant from The Royal Children's Hospital Foundation, Melbourne, Australia (2014-370) and Near-miss funding from the Clinical Sciences Theme, MCRI. The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. Hearps was funded by an Australian National Health and Medical Research Council (NHMRC) Development grant; Babl was funded by The Royal Children's Hospital Research Foundation, an NHMRC Practitioner Fellowship, and a Melbourne Campus Clinician Scientist Fellowship; and Anderson by an NHMRC Senior Practitioner Fellowship. The funding organizations did not have a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
Funding Information:
This study has been approved by the Human Research Ethics Committee of the Royal Children's Hospital Melbourne. The study is funded by a project grant from The Royal Children's Hospital Foundation, Melbourne, Australia (2014-370) and Near-miss funding from the Clinical Sciences Theme, MCRI. The Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. Hearps was funded by an Australian National Health and Medical Research Council (NHMRC) Development grant; Babl was funded by The Royal Children's Hospital Research Foundation, an NHMRC Practitioner Fellowship, and a Melbourne Campus Clinician Scientist Fellowship; and Anderson by an NHMRC Senior Practitioner Fellowship. The funding organizations did not have a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2023
PY - 2023/1
Y1 - 2023/1
N2 - Diffusion-Weight Imaging (DWI) is increasingly used to explore a range of outcomes in pediatric concussion, particularly the neurobiological underpinnings of symptom recovery. However, the DWI findings within the broader pediatric concussion literature are mixed, which can largely be explained by methodological heterogeneity. To address some of these limitations, the aim of the present study was to utilize internationally- recognized criteria for concussion and a consistent imaging timepoint to conduct a comprehensive, multi-parametric survey of white matter microstructure after concussion. Forty-three children presenting with concussion to the emergency department of a tertiary level pediatric hospital underwent neuroimaging and were classified as either normally recovering (n = 27), or delayed recovering (n = 14) based on their post-concussion symptoms at 2 weeks post-injury. We combined multiple DWI metrics across four modeling approaches using Linked Independent Component Analysis (LICA) to extract several independent patterns of covariation in tissue microstructure present in the study cohort. Our analysis did not identify significant differences between the symptomatic and asymptomatic groups and no component significantly predicted delayed recovery. If white matter microstructure changes are implicated in delayed recovery from concussion, these findings, alongside previous work, suggest that current diffusion techniques are insufficient to detect those changes at this time.
AB - Diffusion-Weight Imaging (DWI) is increasingly used to explore a range of outcomes in pediatric concussion, particularly the neurobiological underpinnings of symptom recovery. However, the DWI findings within the broader pediatric concussion literature are mixed, which can largely be explained by methodological heterogeneity. To address some of these limitations, the aim of the present study was to utilize internationally- recognized criteria for concussion and a consistent imaging timepoint to conduct a comprehensive, multi-parametric survey of white matter microstructure after concussion. Forty-three children presenting with concussion to the emergency department of a tertiary level pediatric hospital underwent neuroimaging and were classified as either normally recovering (n = 27), or delayed recovering (n = 14) based on their post-concussion symptoms at 2 weeks post-injury. We combined multiple DWI metrics across four modeling approaches using Linked Independent Component Analysis (LICA) to extract several independent patterns of covariation in tissue microstructure present in the study cohort. Our analysis did not identify significant differences between the symptomatic and asymptomatic groups and no component significantly predicted delayed recovery. If white matter microstructure changes are implicated in delayed recovery from concussion, these findings, alongside previous work, suggest that current diffusion techniques are insufficient to detect those changes at this time.
KW - Diffusion weighted imaging
KW - Mild traumatic brain injury
KW - Pediatric concussion
KW - Pediatric neuroimaging
KW - Persisting post-concussion symptoms
KW - Post-concussion syndrome
UR - http://www.scopus.com/inward/record.url?scp=85169577529&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2023.103486
DO - 10.1016/j.nicl.2023.103486
M3 - Article
C2 - 37634376
AN - SCOPUS:85169577529
SN - 2213-1582
VL - 39
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103486
ER -