Evolutionary history of Salmonella Typhi

Philippe Roumagnac, François Xavier Weill, Christiane Dolecek, Stephen Baker, Sylvain Brisse, Tran Chinh Nguyen, Thi Anh Hong Le, Camilo J. Acosta, Jeremy Farrar, Gordon Dougan, Mark Achtman

Research output: Contribution to journalArticleResearchpeer-review

240 Citations (Scopus)


For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.

Original languageEnglish
Pages (from-to)1301-1304
Number of pages4
Issue number5803
Publication statusPublished - 24 Nov 2006
Externally publishedYes

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