Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

Andrés Opazo-Capurro, Iván San Martín, Mario Quezada-Aguiluz, Felipe Morales-León, Mariana Domínguez-Yévenes, Celia A. Lima, Fernanda Esposito, Louise Cerdeira, Helia Bello-Toledo, Nilton Lincopan, Gerardo González-Rocha

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9 Citations (Scopus)

Abstract

We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB)isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-bla OXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109, ST162, ST15 (CC15)and ST318 (CC15).

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalInfection, Genetics and Evolution
Volume73
DOIs
Publication statusPublished - Sep 2019
Externally publishedYes

Keywords

  • Acinetobacter baumannii
  • Carbapenem-resistance
  • CC15
  • Chile
  • OXA-type carbapenemases
  • WHO's priority-pathogen

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