Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

Amandine Perrin; Elise Larsonneur; Ainsley C. Nicholson; David J. Edwards; Kristin M. Gundlach; Anne M. Whitney; Christopher A. Gulvik; Melissa E. Bell; Olaya Rendueles; Jean Cury; Perrine Hugon; Dominique Clermont; Vincent Enouf; Vladimir Loparev; Phalasy Juieng; Timothy Monson; David Warshauer; Lina I. Elbadawi; Maroya Spalding Walters; Matthew B. Crist; Judith Noble-Wang; Gwen Borlaug; Eduardo P.C. Rocha; Alexis Criscuolo; Marie Touchon; Jeffrey P. Davis; Kathryn E. Holt; John R. McQuiston; Sylvain Brisse

doi:10.1038/ncomms15483

Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

Amandine Perrin, Elise Larsonneur, Ainsley C. Nicholson, David J. Edwards, Kristin M. Gundlach, Anne M. Whitney, Christopher A. Gulvik, Melissa E. Bell, Olaya Rendueles, Jean Cury, Perrine Hugon, Dominique Clermont, Vincent Enouf, Vladimir Loparev, Phalasy Juieng, Timothy Monson, David Warshauer, Lina I. Elbadawi, Maroya Spalding Walters, Matthew B. CristJudith Noble-Wang, Gwen Borlaug, Eduardo P.C. Rocha, Alexis Criscuolo, Marie Touchon, Jeffrey P. Davis, Kathryn E. Holt, John R. McQuiston, Sylvain Brisse

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.

Original language	English
Article number	15483
Number of pages	12
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15483
Publication status	Published - 24 May 2017
Externally published	Yes

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Perrin, A., Larsonneur, E., Nicholson, A. C., Edwards, D. J., Gundlach, K. M., Whitney, A. M., Gulvik, C. A., Bell, M. E., Rendueles, O., Cury, J., Hugon, P., Clermont, D., Enouf, V., Loparev, V., Juieng, P., Monson, T., Warshauer, D., Elbadawi, L. I., Walters, M. S., ... Brisse, S. (2017). Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. Nature Communications, 8, [15483]. https://doi.org/10.1038/ncomms15483

Perrin, Amandine ; Larsonneur, Elise ; Nicholson, Ainsley C. ; Edwards, David J. ; Gundlach, Kristin M. ; Whitney, Anne M. ; Gulvik, Christopher A. ; Bell, Melissa E. ; Rendueles, Olaya ; Cury, Jean ; Hugon, Perrine ; Clermont, Dominique ; Enouf, Vincent ; Loparev, Vladimir ; Juieng, Phalasy ; Monson, Timothy ; Warshauer, David ; Elbadawi, Lina I. ; Walters, Maroya Spalding ; Crist, Matthew B. ; Noble-Wang, Judith ; Borlaug, Gwen ; Rocha, Eduardo P.C. ; Criscuolo, Alexis ; Touchon, Marie ; Davis, Jeffrey P. ; Holt, Kathryn E. ; McQuiston, John R. ; Brisse, Sylvain. / Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. In: Nature Communications. 2017 ; Vol. 8.

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title = "Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain",

abstract = "An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.",

author = "Amandine Perrin and Elise Larsonneur and Nicholson, {Ainsley C.} and Edwards, {David J.} and Gundlach, {Kristin M.} and Whitney, {Anne M.} and Gulvik, {Christopher A.} and Bell, {Melissa E.} and Olaya Rendueles and Jean Cury and Perrine Hugon and Dominique Clermont and Vincent Enouf and Vladimir Loparev and Phalasy Juieng and Timothy Monson and David Warshauer and Elbadawi, {Lina I.} and Walters, {Maroya Spalding} and Crist, {Matthew B.} and Judith Noble-Wang and Gwen Borlaug and Rocha, {Eduardo P.C.} and Alexis Criscuolo and Marie Touchon and Davis, {Jeffrey P.} and Holt, {Kathryn E.} and McQuiston, {John R.} and Sylvain Brisse",

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Perrin, A, Larsonneur, E, Nicholson, AC, Edwards, DJ, Gundlach, KM, Whitney, AM, Gulvik, CA, Bell, ME, Rendueles, O, Cury, J, Hugon, P, Clermont, D, Enouf, V, Loparev, V, Juieng, P, Monson, T, Warshauer, D, Elbadawi, LI, Walters, MS, Crist, MB, Noble-Wang, J, Borlaug, G, Rocha, EPC, Criscuolo, A, Touchon, M, Davis, JP, Holt, KE, McQuiston, JR & Brisse, S 2017, 'Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain', Nature Communications, vol. 8, 15483. https://doi.org/10.1038/ncomms15483

Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. / Perrin, Amandine; Larsonneur, Elise; Nicholson, Ainsley C.; Edwards, David J.; Gundlach, Kristin M.; Whitney, Anne M.; Gulvik, Christopher A.; Bell, Melissa E.; Rendueles, Olaya; Cury, Jean; Hugon, Perrine; Clermont, Dominique; Enouf, Vincent; Loparev, Vladimir; Juieng, Phalasy; Monson, Timothy; Warshauer, David; Elbadawi, Lina I.; Walters, Maroya Spalding; Crist, Matthew B.; Noble-Wang, Judith; Borlaug, Gwen; Rocha, Eduardo P.C.; Criscuolo, Alexis; Touchon, Marie; Davis, Jeffrey P.; Holt, Kathryn E.; McQuiston, John R.; Brisse, Sylvain.

In: Nature Communications, Vol. 8, 15483, 24.05.2017.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Gundlach, Kristin M.

AU - Whitney, Anne M.

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AU - Bell, Melissa E.

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AU - Cury, Jean

AU - Hugon, Perrine

AU - Clermont, Dominique

AU - Enouf, Vincent

AU - Loparev, Vladimir

AU - Juieng, Phalasy

AU - Monson, Timothy

AU - Warshauer, David

AU - Elbadawi, Lina I.

AU - Walters, Maroya Spalding

AU - Crist, Matthew B.

AU - Noble-Wang, Judith

AU - Borlaug, Gwen

AU - Rocha, Eduardo P.C.

AU - Criscuolo, Alexis

AU - Touchon, Marie

AU - Davis, Jeffrey P.

AU - Holt, Kathryn E.

AU - McQuiston, John R.

AU - Brisse, Sylvain

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